Once daily treatment with terbinafine 1% cream (LamisilR) for one week is effective in the treatment of tinea corporis and cruris. A placebo-controlled study

Budimulja, Unandar; Bramono, Kusmarinah; Urip, K. S.; Basuki, Sulistyo; Widodo, G.; Rapatz, G.; Paul, Carle

doi:10.1046/j.1439-0507.2001.d01-88.x

Cited by 2 publications

(3 citation statements)

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“…The results of the literature search are shown in Figure . Of the 364 references identified from the searches, 129 studies met our inclusion criteria . However, 63 of these contained no usable or retrievable data owing mainly to the unavailability of separate data for the different tinea infections (Table S1; see Supporting Information) .…”

Section: Resultsmentioning

confidence: 99%

“…However, 63 of these contained no usable or retrievable data owing mainly to the unavailability of separate data for the different tinea infections (Table S1; see Supporting Information) . The characteristics of the remaining 66 studies are summarized in Table . Of the 129 included studies, 27 had a placebo arm as control, 98 had an active control arm and four studies included both.…”

Section: Resultsmentioning

confidence: 99%

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Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review

2015

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Tinea cruris and tinea corporis are common fungal infections. Most can be treated with a variety of topical antifungals. This review aimed to assess the evidence for the effectiveness and safety of topical treatments for tinea cruris and tinea corporis. Searches included the Cochrane Skin Group Specialised Register, CENTRAL in The Cochrane Library, Medline, Embase, LILACS and ongoing trials registries (August 2013). One hundred and twenty-nine randomized controlled trials (RCTs) with 18 086 participants evaluated a range of interventions - mostly azoles. Pooling of data for several outcomes was only possible for two individual treatments. In five studies, terbinafine showed a statistically significant higher clinical cure rate compared with placebo [risk ratio (RR) 4·51, 95% confidence interval (CI) 3·10-6·56]. Data for mycological cure could not be pooled owing to substantial heterogeneity. Across three studies, mycological cure rates favoured naftifine (1%) compared with placebo (RR 2·38, 95% CI 1·80-3·14) but the quality of the evidence was low. Combinations of azoles with corticosteroids were slightly more effective than azoles for clinical cure, but there was no statistically significant difference with regard to mycological cure. Sixty-five studies were assessed as 'unclear' and 64 as being at 'high risk' of bias; many were over 20 years old, and most were poorly designed and inadequately reported. Although most active interventions showed sufficient therapeutic effect, this review highlights the need for further, high-quality, adequately powered RCTs to evaluate the effects of these interventions, which can ultimately provide reliable evidence to inform clinical decision making.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review

2015

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“…Early studies indicated that twice‐daily treatment with 1% terbinafine for 1 week was as effective as twice‐daily administration of clotrimazole 1% for 4 weeks 83,84 . Recent studies have demonstrated that terbinafine 1% is effective with once‐daily treatment 85–87 . A recently developed terbinafine 1% emulsion gel formulation has been shown to be significantly more effective than placebo when applied once daily for 7 days in a study of 101 patients with tinea pedis 86 .…”

Section: Do Approaches Employed To Improve Adherence To Oral Therapy mentioning

confidence: 99%

Adherence to topical dermatological therapy: lessons from oral drug treatment

Gupta

Mallefet

Kress

et al. 2009

British Journal of Dermatology

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Patients are remarkably nonadherent to medical treatment regimens across all diseases and classes of therapy, and it has been estimated that nonadherence to drug treatment is responsible for as many as 10% of all hospital admissions. Nonadherence to treatment also has significant negative effects on treatment outcomes across a wide range of diseases. Patient-related factors such as age, ethnicity, literacy (including health literacy), health beliefs, and socioeconomic conditions have been shown to influence adherence to oral therapy. Medication-related factors, such as regimen complexity and duration of treatment, also impact on adherence. Variables that significantly influence adherence to oral drugs have similar effects on adherence to topical therapy. Both educational and psychological interventions along with simplification of dosing regimens can significantly improve adherence to oral therapy and limited evidence indicates that these approaches are also effective in patients receiving topical therapy. There is very little information about the effects of dosing regimens on adherence to topical medical therapy. The advent of new drug formulations that permit once-daily or single-dose drug application will, however, permit evaluation of different topical treatment regimens on adherence and treatment outcomes in patients with dermatological disease.

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Once daily treatment with terbinafine 1% cream (LamisilR) for one week is effective in the treatment of tinea corporis and cruris. A placebo-controlled study

Cited by 2 publications

References 0 publications

Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review

Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review

Adherence to topical dermatological therapy: lessons from oral drug treatment

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