2018
DOI: 10.1155/2018/8321871
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Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients

Abstract: Purpose Radiation therapy is a key treatment of breast cancer. Elderly patients with associated diseases that modify their performance status do not tolerate long periods of daily irradiation. The objective of this study is to analyze the results of weekly hypofractionated treatment in these patients. Material and Methods Between 1992 and 2016, we included 486 elderly patients presenting concomitant pathology or sociofamilial problems in which it was not feasible to propose conventional treatment. They were tr… Show more

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Cited by 26 publications
(25 citation statements)
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“…Locoregional control was similar in both arms, with no difference in cosmesis or late toxicity profile. Additional studies investigating the safety and efficacy of a once-weekly regimen have demonstrated similar results [16,17].…”
Section: Further Hypofractionationmentioning
confidence: 83%
“…Locoregional control was similar in both arms, with no difference in cosmesis or late toxicity profile. Additional studies investigating the safety and efficacy of a once-weekly regimen have demonstrated similar results [16,17].…”
Section: Further Hypofractionationmentioning
confidence: 83%
“…Preliminary data suggests that hypofractionation is an effective radiotherapy schedule with acceptable toxicity for older cancer patients either as a single modality or combined with chemotherapy [54,55,56]. Preliminary studies suggested that hypofractionation may be effective in both curative and palliative settings for local control and improvement of patient quality of life in older cancer patients with various types of tumor [57,58,59].…”
Section: Discussionmentioning
confidence: 99%
“…Finally, for older patients [14] for whom surgery is probably not indicated, a hypofractional scheme is proposed (6.5 Gy weekly for 5 weeks up to a total dose of 32.5 Gy), with a possible boost of two fractions of 6.5 Gy. In this scenario, if lymph nodes are to be included, they will be irradiated with 5.5‐Gy fractions up to a total dose of 27.5 Gy.…”
Section: Resultsmentioning
confidence: 99%