Onchocerciasis in Yemen: Time to take action against a neglected tropical parasitic disease

Abdul‐Ghani, Rashad; Mahdy, Mohammed A. K.; Beier, John C.

doi:10.1016/j.actatropica.2016.06.017

Cited by 12 publications

(6 citation statements)

References 40 publications

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“…Sowda, a lichenified onchodermatitis prevalent in Yemen is an hyperreactive skin condition characterized by intense pruritus and hyperpigmentation of the skin mainly affecting the legs below the knees, but may extend to the thighs and gluteal region, with common secondary suppurative and papular dermatitis (22); [Michele,(23)]. In Central America, another manifestation of acute Onchocerciasis includes facial swelling with itching and erythema, a finding known as erysipelas de la costa.…”

Section: Onchocercal Skin Diseasementioning

confidence: 99%

Onchocerciasis: Current knowledge and future goals

et al. 2022

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Human Onchocerciasis, caused by infection by the filarial nematode Onchocerca volvulus, is a neglected public health disease that affects millions of people in the endemic regions of sub-Saharan Africa and Latin America. It is also called river blindness because the Blackflies that transmit infection breeds in rapidly flowing fresh water streams and rivers. This review features state-of-the-art data on the parasite, its endobacteria Wolbachia, the prevalence of the infection and its geographical distribution, its diagnostics, the interaction between the parasite and its host, and the pathology of Onchocerciasis. By development and optimization of the control measures, transmission by the vector has been interrupted in foci of countries in the Americas (Colombia, Ecuador, Mexico, and Guatemala)and inSudan, followed by Onchocerciasis eliminations. The current state and future perspectives for vector control and elimination strategy are described.

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Section: Onchocercal Skin Diseasementioning

confidence: 99%

Onchocerciasis: Current knowledge and future goals

et al. 2022

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“…Of helminthic NTDs, onchocerciasis is considered the most neglected of parasitic NTD in Yemen, mostly affecting the poorest rural communities (5). It is noteworthy that a national action plan to eliminate the disease from the country by 2015 based on mass ivermectin distribution and vector control, was established in 2010 (6).…”

Section: Onchocerciasis and Lymphatic Filariasismentioning

confidence: 99%

Combat against Neglected Parasitic Diseases in Yemen: The Need for Mapping as a Prerequisite for Elimination

Abdul‐Ghani¹

2017

Yemeni J Med Sci

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Besides poverty, war and social unrest, Yemen is afflicted with the majority of neglected tropical diseases (NTDs) listed by the World health organization, particularly parasitic ones. Despite the efforts made by some control and elimination programmes, there is a lack of reliable mapping services that could help to identify the top-priority endemic areas and at-risk populations and to monitor the effectiveness of past and ongoing efforts to eliminate parasitic NTDs. Therefore, most of the NTD burden iceberg in Yemen is still submerged and needs to be assessed, mapped and stratified for the implementation of cost-effective elimination interventions. Availability of accessible data on the burden of parasitic diseases as well as mass drug administration in endemic areas is a prerequisite for any successful cost-effective elimination efforts. The establishment of an open-access national NTDs mapping center in Yemen should be considered as a databank for researchers, policy makers and funding bodies.

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“…Infection outbreaks were also recorded in Yemen, Oman and Saudi Arabia. On a smaller scale, outbreaks were reported in Ecuador, Venezuela, Colombia, southern Mexico and Guatemala [10, 11]. According to the World Health Organisation (WHO), 99% of people infected worldwide live in 31 sub-Saharan countries [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Analysis of severe adverse effects following community-based ivermectin treatment in the Democratic Republic of Congo

Bof

Muteba²,

Mansiangi

et al. 2019

BMC Pharmacol Toxicol

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Background The progress of mass, community-directed, treatment with ivermectin (CDTI) for onchocerciasis control was disrupted by severe adverse effects (SAE) in the Democratic Republic of Congo (DRC). The study aimed at determining the frequency of post-CDTI SAE as well as factors associated with the occurrence of SAE. Methods Our retrospective study relied on SAE collection cards, as archived by the DRC Ministry of Health, and compiled for people who benefited from ivermectin treatment then further developed SAE. The study included 945 post-CDTI SAE recorded in DRC between 2003 and 2017. These cases occurred in 15 projects out of 22 projects implemented in the country. All cards were reviewed and analysed. Results Between the years 2003 and 2017, the total average population treated was around 15,552,588 among which 945 cases of SAE were registered in DR Congo, i.e. 6 cases of SAE for 100,000 persons treated per year. 55 deaths related to post-CDTI SAE were recorded, which represents 5.8% of all cases of SAE. Non-neurological SAE were dominated by severe headaches (74.8%), myalgia (64.0%) and arthralgia (62.7%). Neurological SAE were mainly coma (94.1%), motor deficit (75.4%) and palpebral subconjunctival haemorrhages (38.8%). Factors associated with the occurrence of SAE were: male, age over 18 years old, alcohol consumption, hemp intake and the presence of loiasis. The study also highlighted weaknesses of the National Program for Onchocerciasis Control (NPOC) in terms of awareness campaigns among the population. Conclusion Co-endemicity of loiasis and onchocerciasis is one of the key factors responsible for the occurrence of SAE following ivermectin treatment. Mobilization of resources necessary to the appropriate management of SAE and awareness of populations are essential to achieve onchocerciasis control in DRC.

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Onchocerciasis in Yemen: Time to take action against a neglected tropical parasitic disease

Cited by 12 publications

References 40 publications

Onchocerciasis: Current knowledge and future goals

Onchocerciasis: Current knowledge and future goals

Combat against Neglected Parasitic Diseases in Yemen: The Need for Mapping as a Prerequisite for Elimination

Analysis of severe adverse effects following community-based ivermectin treatment in the Democratic Republic of Congo

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