Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer

Duan, Jingjing; Zhang, Haiyang; Qu, Yanjun; Deng, Ting; Huang, Dingzhi; Liu, Rui; Zhang, Le; Bai, Ming; Zhou, Lyu; Ying, Guoguang; Ba, Yi

doi:10.18632/oncotarget.9936

Cited by 61 publications

(47 citation statements)

References 36 publications

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“…For instance, miR-23b could function as a tumor suppressor that present downregulation in stomach cancer (35) and bladder cancer (36). Whereas the miR-130 family have been identified as upregulated in many cancer types that representing putative oncogene (37,38). This pan-cancer wide meta-profiling analysis indicated that the comprehensive investigation of the database may help to illuminate the complicated relationship between miRNAs and cancers and develop more effective treatment strategies for cancers.…”

Section: Discussionmentioning

confidence: 99%

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

et al. 2016

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MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important role in cancer development. Large amount of differentially expressed miRNAs have been identified in various cancers by using high-throughput methods. It is therefore quite important to make a comprehensive collection of these miRNAs and to decipher their roles in oncogenesis and tumor progression. In 2010, we presented the first release of dbDEMC, representing a database for collection of differentially expressed miRNAs in human cancers obtained from microarray data. Here we describe an update of the database. dbDEMC 2.0 documents 209 expression profiling data sets across 36 cancer types and 73 subtypes, and a total of 2224 differentially expressed miRNAs were identified. An easy-to-use web interface was constructed that allows users to make a quick search of the differentially expressed miRNAs in certain cancer types. In addition, a new function of ‘meta-profiling’ was added to view differential expression events according to user-defined miRNAs and cancer types. We expect this database to continue to serve as a valuable source for cancer investigation and potential clinical application related to miRNAs. dbDEMC 2.0 is freely available at http://www.picb.ac.cn/dbDEMC.

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Section: Discussionmentioning

confidence: 99%

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

et al. 2016

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“…Wei H and colleagues found that miR-130a as an oncogenic miRNA that targets PTEN to drive malignant cell survival and tumor growth [45]. Additionally, miR130a was reported as an oncogene by directly targeting TGFβR2 in gastric cancer [46]. The expression level and biological functions of miR-130a-3p in glioma remains unclear yet.…”

Section: Discussionmentioning

confidence: 99%

H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Yin

Zeng

et al. 2018

Cell Physiol Biochem

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Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in human glioma tissues and cell lines, and is associated with tumor progression thus predicating clinical outcomes in glioma patients. However, the overall biological functions and their mechanism of H19 in glioma are not fully understood. Methods: Firstly, we analyzed H19 alterations in different grades of glioma tissues through an analysis of 5 sequencing datasets and qRT-PCR was performed to confirm the results. Next, we evaluated the effect of H19 on glioma cells migration, invasion and EMT process. Luciferase assays and RIP assays were employed to figure out the correlation of H19 and SOX4. Results: H19 was overexpressed in glioma tissues. Down-regulation of H19 led to the inhibition of migration, invasion and EMT process with a reduction in N-cadherin and Vimentin. H19 and SOX4 are both direct target of miR-130a-3p. H19 could compete with SOX4 via sponging miR-130a-3p. Conclusion: Taken together, these results provide a possible function of H19 as an oncogene in glioma tissues and provide a potential new therapeutic strategy for human glioma.

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“…Previously, miRNAs have been demonstrated to be functionally involved in the regulation of a series of physiological and pathological processes, including cell proliferation, apoptosis, differentiation and invasion (9). Alterations in the expression of miRNAs have been widely reported in almost all types of cancer, including hepatocellular carcinoma (10), cervical (11), thyroid (12), colorectal (13) and gastric cancer (14). Previous studies have demonstrated that expression levels of miRNAs are associated with cancer initiation and progression (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway

2018

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Abstract. Gastric cancer is the fourth most common cancer and the second most frequent cause of cancer-associated mortality in the world. Previous studies have revealed that expression levels of microRNAs (miRNAs) are associated with the initiation and progression of several types of cancer, including gastric cancer. Previous studies have demonstrated that the abnormal expression of miRNA-136 may serve a function in the progression of several types of human cancer. However, the expression pattern of miR-136, its functions and underlying molecular mechanisms in gastric cancer remain unresolved. In the present study, it was revealed that the expression of miR-136 was aberrantly up regulated in gastric cancer tissues and cell lines. The suppression of miR-136 was able to inhibit proliferation and invasion in gastric cancer cell lines. Furthermore, phosphatase and tensin homolog (PTEN) was identified as a direct target gene of miR-136 in gastric cancer. PTEN was under expressed in gastric cancer tissues compared with non-tumor gastric tissues, and PTEN expression was negatively correlated with miR-136 expression. Furthermore, PTEN overexpression mimics the effects of miR-136 knockdown on gastric cancer cells. Additionally, miR-136 under expression decreased phospho-(p) AKT expression, but did not affect AKT expression in gastric cancer cells. In conclusion, the data of the present study suggest that miR-136 acts as an oncogene in gastric cancer via regulation of the PTEN/AKT/p-AKT signaling pathway and may potentially serve as a novel therapeutic target for the treatment of gastric cancer.

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Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer

Cited by 61 publications

References 36 publications

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers

H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway

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