Oncocytic Carcinoid of The Lung an Ultrastructural Observation

Kuwahara, Takeichiro; Maruyama, Koshi; Mochizuki, S; Seki, Yasuo; Sawada, Kinya

doi:10.1111/j.1440-1827.1984.tb07563.x

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…Neuroendocrine tumours in other organs containing dispersed neuroendocrine cells have been occasionally reported [5,6,14,16,21,23,41]. In the pancreas, endocrine tumours composed of oncocytic cells have been described also, either sporadic [8,15,28,33,36,37] or associated to inherited multiple endocrine tumour syndromes such as Von Hippel-Lindau disease [10].…”

Section: Discussionmentioning

confidence: 97%

“…Non-neoplastic lesions formed of oncocytes are described in the thyroid, parathyroid, salivary and respiratory mucosal glands, whereas oncocytic tumours are more widely distributed and can be observed in all the above tissues as well as in several other organs such as the kidney and pituitary. Neuroendocrine tumours with oncocytic features are very rare, and few case reports have been published of tumours in the thyroid [16], lung [14,21], larynx [41], stomach [5,6] and thymus [24].…”

Section: Introductionmentioning

confidence: 99%

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Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas

et al. 2006

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Oncocytic changes may occur very infrequently in neuroendocrine tumours. To estimate the prevalence, pathological features and clinical behaviour of oncocytic endocrine tumours of the pancreas, we reviewed a series of 227 lesions from two institutions. Eleven cases with predominant oncocytic features were selected, representing 4.85% of the whole series. The morphological features and immunophenotype of such tumours did not differ from conventional endocrine pancreatic tumours, except for the presence of abundant eosinophilic and granular cytoplasm. Anti-mitochondrial antigen was positive in all cases tested, and by electron microscopy, numerous mitochondria were observed in the cytoplasm of tumour cells. The majority of cases were nonfunctioning, and in most cases, pathologic signs of malignancy, leading to a diagnosis of endocrine carcinoma, were observed. In addition, the three nonmalignant cases matched the criteria of well-differentiated tumours of uncertain malignant potential. Nearly 50% of the cases were clinically aggressive, and lymph node and liver metastases were present at the time of diagnosis in a minority of cases. Therefore, oncocytic endocrine pancreatic tumours represent a peculiar morphological and clinical variant characterised by frequent hormonal inactivity and malignant behaviour, which should be considered in the differential diagnosis, especially when dealing with a metastatic lesion.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas

et al. 2006

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“…Oncocytic carcinoid tumors have been reported in the nasopharynx [5], thymus [6], lung, pancreas [7], kidney [8], and urinary bladder [9]. Oncocytic carcinoid tumor of the lung has been reported in 11 single-case reports [10][11][12][13][14][15][16][17][18][19][20] and 1 case in a series analysis of carcinoid tumors [3].…”

Section: Introductionmentioning

confidence: 98%

Oncocytic neuroendocrine tumors of the lung: histopathologic spectrum and immunohistochemical analysis of 15 cases

Tsuta¹,

Kalhor²,

Raso³

et al. 2011

Human Pathology

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