Oncocytic carcinoma of parotid gland: Fine‐needle aspiration and histologic findings

Abstract

A parotid gland mass in an elderly man was diagnosed as an oncocytic neoplasm with cellular pleomorphism and cytologic atypia by fine-needle aspiration. The histologic features showed a primary parotid malignant oncocytoma with metastasis in regional lymph nodes.

Oncocytic Carcinoma of the Parotid Gland

“…6,[10][11][12][13] However, the oncocytic nature was confirmed in only three cases. 6,12,13 Electron microscopy and/or PTAH staining was used to show the presence of numerous cytoplasmic mitochondria in earlier studies.…”

“…6,[10][11][12][13] However, the oncocytic nature was confirmed in only three cases. 6,12,13 Electron microscopy and/or PTAH staining was used to show the presence of numerous cytoplasmic mitochondria in earlier studies. 6,12,13 In the present report, we readily showed immunoreactivity of the tumor cytoplasm by immunocytochemistry using monoclonal antimitochondrial antibody.…”

“…6,11,12 Rarely is cytologic atypia, such as cellular polymorphism, nuclear pleomorphism and hyperchromatism, consistent with a malignant tumor of an oncocytic nature. 13 Oncocytoid adenocarcinoma appears as single cells with eccentric nuclei in contrast to the cohesive clusters of oncocytic carcinoma. 7 Occasionally the acinic cells resemble oncocytes, and this may cause problems in differentiating acinic cell carcinomas from oncocytic tumors.…”

“…6,12,13 Electron microscopy and/or PTAH staining was used to show the presence of numerous cytoplasmic mitochondria in earlier studies. 6,12,13 In the present report, we readily showed immunoreactivity of the tumor cytoplasm by immunocytochemistry using monoclonal antimitochondrial antibody. This result corresponded to our electron microscopic observations of the tumor cells and immunohistochemistry using the same antibody.…”

Salivary Gland Tumors with a Prominent Oncocytic Component

“…9 Acceptable criteria for the diagnosis of malignancy are local infiltration, perineural or intravascular invasion and the presence of regional or distant metastases. 14 The diagnosis of oncocytic carcinoma on aspirated material has been reported. 2,14,20 A review of several large series on FNAC of salivary gland lesions revealed little about diagnostic accuracy in oncocytomas.…”