Oncocytic Lesions of Salivary Glands with Morphological and Immunohistochemical Finding

Hasçiçek, Seyhan Özakkoyunlu; Tunçel, Deniz; Ünsal, Özlem; Kabukçuoğlu, Fevziye

doi:10.14744/semb.2018.04935

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…As the clinical presentation and imaging features of benign and malignant oncocytic neoplasms often overlap, histology is crucial for distinguishing benign oncocytomas from malignant oncocytic carcinomas. Due to their high mitochondrial contents, all oncocytes react to histochemical stains for mitochondria, including phosphotungstic acid-hematoxylin [21 , 27 , 28] . Oncocytic neoplasms are also stained by cytokeratin markers (KL-1).…”

Section: Discussionmentioning

confidence: 99%

“…Whereas benign oncocytomas consist of organized sheets of oncocytes, oncocytic carcinoma exhibits significant cellular atypia, higher mitotic activity, vascular and perineural invasion, and metastases [20 , 28 , 29] . In particular, locally infiltrative growth is needed for diagnosing oncocytic carcinoma [27] . Compared to benign oncocytomas, oncocytic carcinoma stains more strongly with MIB-1 and Ki-67 due to higher mitotic activity [28 , 29] .…”

Section: Discussionmentioning

confidence: 99%

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Oncocytic carcinoma of the parotid gland as a manifestation of Birt-Hogg-Dube syndrome

Chen¹,

Siu²,

Bastawrous³

et al. 2023

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oncocytic carcinoma of the parotid gland as a manifestation of Birt-Hogg-Dube syndrome

Chen¹,

Siu²,

Bastawrous³

et al. 2023

Radiology Case Reports

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“…Meanwhile, oncocytic carcinoma is uncommon in the parotid gland and accounts for less than 1% of all salivary gland tumors. [1][2][3][4] It is characterized by atypic oncocytes, frequent mitosis, destruction and invasion of adjacent structures, and metastasis. The recurrence reported in ranging from 25% to 52% of cases.…”

Section: Introductionmentioning

confidence: 99%

Oncocytic Carcinoma of Parotid Gland: A Case Report

Lumintang

Tandililing

Ekawati

2023

eCl

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Oncocytic carcinoma is a rare malignant carcinoma, representing only 5% of all oncocytic tumors. Furthermore, oncocytic carcinoma of the parotid gland is uncommon, accounting only for under 1% of all salivary gland tumors. We reported an 82-year-old female presented with a right parotid mass. She had experienced a similar complaint six months ago and had undergone treatment. Physical examination showed a mobile and painless cystic mass of the right parotid without facial nerve involvement. Fine needle aspiration biopsy (FNAB) finding suggested benign cystic lesions with inflammatory cells and amorphous debris. Subsequently, she underwent surgical tumor excision and right-sided partial parotidectomy. Histopathological examination showed proliferative tumor cells with an atypical nucleus, abundant eosinophilic cytoplasm, and solid, trabecular, and tubular growth pattern, suggesting an oncocytic carcinoma of the parotid gland. In conclusion, oncocytic carcinoma must be considered in all parotid gland tumors with oncocytic cells despite the rarity. Considering its recurrence and metastasis nature, patients with oncocytic carcinoma should remain in a long-term follow-up. The role of radiotherapy and chemotherapy remains controversial but may be used for treating advanced-stage cases or distant metastasis Keywords: oncocytic carcinoma; parotid gland; partial parotidectomy

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“…Oncocytic neoplasms of the salivary glands represent a diverse group of tumors characterized morphologically by the predominance of oncocytic cells. [1][2][3] Except for Warthin's tumor, salivary gland tumors with oncocyte predominance are uncommon and include oncocytoma, oncocytic carcinoma (OCs), and oncocytic cystadenoma. However, other tumors can also exhibit oncocytic features such as pleomorphic adenoma, myoepithelioma, sialolipoma, mucoepidermoid carcinoma, and epithelial-myoepithelial carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

et al. 2021

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Oncocytic lipoadenoma (OL) is a rare salivary gland tumor characterized by the presence of oncocytic cells and mature adipose tissue. To date, only 30 cases of OL have been reported in the English-language literature. We present 3 additional OL cases involving the parotid, including a synchronous presentation with paraganglioma of the right carotid bifurcation. Microscopically, both the OLs were composed of a mixed population of oncocytes and adipocytes in varying proportions surrounded by a thin, connective tissue fibrous capsule. Oncocytes were positive for pan-cytokeratins (CKs) AE1/AE3, epithelial membrane antigen, CK5, CK7, CK14, CK18, and CK19. Calponin, p63, alpha-smooth muscle actin, and carcinoembryonic antigen were negative. Vimentin and S-100 protein were positive only in adipose cells. Despite distinctive morphologic features, OL is often misdiagnosed, given its rarity. We hope to contribute to surgeons’ and pathologists’ awareness and knowledge regarding the existence of this tumor and provide adequate management through conservative surgical excision.

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Oncocytic Lesions of Salivary Glands with Morphological and Immunohistochemical Finding

Cited by 5 publications

References 23 publications

Oncocytic carcinoma of the parotid gland as a manifestation of Birt-Hogg-Dube syndrome

Oncocytic carcinoma of the parotid gland as a manifestation of Birt-Hogg-Dube syndrome

Oncocytic Carcinoma of Parotid Gland: A Case Report

Oncocytic Lipoadenoma: Report of 3 Rare Cases Involving the Parotid Gland, Including a Synchronous Presentation With Paraganglioma of the Right Carotid Bifurcation and Literature Review

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