Oncocytic papillary cystadenoma of the larynx: comparative study of ten cases and review of the literature

Švejdová, Anna; Kalfeřt, David; Školoudík, Lukáš; Šatanková, Jana; Laco, Ján; Čelakovský, Petr; Chrobok, Viktor

doi:10.1007/s00405-021-06841-2

Cited by 8 publications

(17 citation statements)

References 18 publications

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“…The OPC is instead of much rarer occurrence, representing less than 1% of benign tumors of the minor salivary glands. Its occurrence in the larynx predominantly involves the supraglottic level (74% of cases), specifically affecting the ventricles rather than the false vocal cords [ 15 ]. Typically presenting as an isolated tumor, the treatment of choice is excision using CO 2 laser.…”

Section: Discussionmentioning

confidence: 99%

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Oncocytic papillary cystadenoma of the larynx: a case report

Caranti,

Spasiano,

Piantanida

et al. 2024

J Med Case Reports

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Background Cystadenoma of the salivary glands is a rare benign clinical condition affecting both major and minor salivary glands equally. It constitutes approximately 2% of total neoplasms and 4.2–4.7% of benign formations in minor salivary glands. Typically presenting as a slow-growing, painless neoplasm, it can be distinguished from Cystadenolymphoma (Whartin’s Tumor) by the absence of lymphoid elements in histological examination. While mostly located in the oral cavity and oropharynx, it can also be found in sinonasal mucosa, and rare cases have been identified in the larynx. Case presentation A 75-year-old Caucasian woman presented to the ear, nose, and throat department with complaints of dysphonia and headaches persisting for several months. Dysphonia had developed months after an unspecified vocal cord surgery elsewhere. Flexible laryngoscopy identified a left-sided cystic swelling affecting the supraglottic space, leading to respiratory obstruction and dysphonia. Head and neck computed tomography confirmed a 1.9 × 1.7 cm bilobed cystic mass originating from the left Morgagni ventricle. Microlaryngoscopy with CO2 laser excision and biopsy revealed a histopathological diagnosis of oncocytic papillary cystadenoma. Post-surgery, the patient fully recovered from dysphonia, with no significant complications noted. Long-term clinical surveillance was advised to detect potential recurrences promptly. Conclusion Ectopic minor salivary gland tumors, both benign and malignant, should be taken into consideration as potential differential diagnosis for any swelling arising within the upper digestive tract mucosa. Ears, nose, and throat clinical examination completed by videolaryngoscopy can easily point out the location of the mass. Imaging is mandatory for differential diagnosis and for surgical planning. Surgical excision can provide both diagnosis and definitive cure.

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Section: Discussionmentioning

confidence: 99%

“…Typically presenting as an isolated tumor, the treatment of choice is excision using CO 2 laser. However, there are reported rare cases of very voluminous tumors or multiple localizations, which have necessitated open laryngectomy rather than total laryngectomy [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Oncocytic papillary cystadenoma of the larynx: a case report

Caranti,

Spasiano,

Piantanida

et al. 2024

J Med Case Reports

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“…OPCs are benign neoplasms rarely encountered in the head and neck region [ 6 ]. They have been reported to appear in the accessory tear glands, salivary glands, buccal mucosa, nasopharynx, oropharynx, and larynx [ 3 , 6 ]. Their presence in the larynx is extremely rare (less than 1% of all laryngeal tumors), accounting for approximately 150 cases in the literature [ 2 , 3 , 5 , 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Oncocytic Papillary Cystadenoma: A Case of a Misdiagnosed Laryngeal Mass

Kanioura,

Riga,

Potamianos

et al. 2024

Cureus

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Cystadenomas are benign neoplasms found in major and minor salivary glands. In cases where both oncocytic cells and papillary architecture, without a lymphoid component, exist, the lesion is called oncocytic papillary cystadenoma (OPC). OPCs are rarely encountered in the laryngeal region and that is why they are usually misdiagnosed as other types of laryngeal tumors. Hereby, we present a case of a misdiagnosed laryngeal OPC in an attempt to raise awareness of this rare entity, both for the surgeon performing the excision of the laryngeal mass and for the pathologists examining the specimen.

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“…Oncocytic cysts or cystadenomas of the larynx are rare histologically benign lesions that account for only 0.1–1% of laryngeal lesions [ 12 ]. They were first described independently by both Koschier and Schaffer in 1897, and up to 2007, there were only 150 published cases in the literature [ 13 – 15 ]. The lining oncocytes represent hypertrophic epithelial cells that contain numerous mitochondria resulting in the characteristic abundant eosinophilic cytoplasm [ 16 ] as can be seen in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Very rarely they may be subglottic and multiple [ 17 , 18 ]. Most often, there is a history of smoking with the lesions being diagnosed in women over the age of 60 years [ 13 ]. Treatment is by local excision with follow-up for recurrences [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal oncocytic cystadenoma and sudden death

Gilbert

Byard

2022

Forensic Sci Med Pathol

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An 86-year-old woman with Alzheimer disease collapsed in her nursing home and was not able to be resuscitated. At autopsy, the major findings were in the larynx where a pedunculated oncocytic cystadenoma had occluded the glottis. Oncocytic cysts or cystadenomas of the larynx are rare histologically benign lesions that account for only 0.1–1% of laryngeal lesions. While the usual presentation is of a sensation of a mass in the throat, hoarseness, or stridor, very occasionally, there may be acute airway compromise and sudden death. Oncocytic cystadenoma should, therefore, be included in the differential diagnosis of potentially lethal obstructive laryngeal lesions.

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Oncocytic papillary cystadenoma of the larynx: comparative study of ten cases and review of the literature

Cited by 8 publications

References 18 publications

Oncocytic papillary cystadenoma of the larynx: a case report

Oncocytic papillary cystadenoma of the larynx: a case report

Oncocytic Papillary Cystadenoma: A Case of a Misdiagnosed Laryngeal Mass

Laryngeal oncocytic cystadenoma and sudden death

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