Oncocytic pleomorphic adenoma of the parotid gland

Abstract

A rare case of salivary gland pleomorphic adenoma, in which the majority of cells were oncocytic, is reported. The patient, a 53-year-old man, presented with a parotid gland mass that was otherwise asymptomatic. Surgical treatment consisted of a superficial parotid lobectomy. The specimen was prepared in standard fashion and studied by light and electron microscopy. The microscopic features were characteristic of salivary gland pleomorphic adenomas, however, both epithelial and "mesenchymal" elements were oncocytic. Such changes may occur focally in pleomorphic adenomas, but we were unable to find documentation of a wholly oncocytic variant in a review of the medical literature. From our clinical data and previous reports of pleomorphic adenomas with focal oncocytosis, it is concluded that such changes likely do not alter prognosis in affected patients. The possible significance of this lesion in regard to the histogenesis of salivary gland pleomorphic adenomas is discussed.

Oncocytic myoepithelioma and pleomorphic adenoma of the salivary glands

“…As a minor component there are several tumours in which it is not uncommon, but to our knowledge, only one PA composed predominantly of oncocytic cells has been reported in the literature [28], and we have been unable to find any description of a pure oncocytic variant of ME similar to those presented in this paper.…”

“…We have therefore reviewed our archives, and here describe the clinical, histological and immunohistochemical findings in 20 cases of pure oncocytic MEs and myoepithelial-rich PAs with widespread oncocytic metaplasia of modified neoplastic myoepithelial cells. We are not aware of any papers specifically addressing the topic of oncocytic changes in myoepithelial tumours, with the exception of sporadic case reports [16][17][18]28]. We also include some previously unreported features.…”

Oncocytic changes in pleomorphic adenoma: Report of a rare case

“…The surgical treatment for the oncocytic pleomorphic adenoma is complete wide surgical excision with good safety margins. [ 10 11 ]…”

Cytologic features of oncocytic pleomorphic adenoma

“…[1][2][3] In this communication, we present cytologic findings in a case of oncocytic PA. However, few histologic reports describe PA in which the majority of cells are oncocytic.…”

“…[1][2][3] In this communication, we present cytologic findings in a case of oncocytic PA.A 61-yr-old man was submitted to our department for fine-needle aspiration cytology of a slowly growing mass located in the region of the right parotid gland. However, few histologic reports describe PA in which the majority of cells are oncocytic.…”