2019
DOI: 10.1136/gutjnl-2018-317440
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Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance

Abstract: Background and aimsThe unique expression pattern makes oncofetal proteins ideal diagnostic biomarkers and therapeutic targets in cancer. However, few oncofetal proteins have been identified and entered clinical practice.MethodsFetal liver, adult liver and hepatocellular carcinoma (HCC) tissues were employed to assess the expression of hepatic leukaemia factor (HLF). The impact of HLF on HCC onset and progression was investigated both in vivo and in vitro. The association between HLF and patient prognosis was d… Show more

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Cited by 99 publications
(70 citation statements)
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“…Various numbers of Huh7/HepG2 miR-361-3p mimic or miR-361-3p sponge and their control cells were digested and seeded into 96-well ultra-low attachment (2,4,8,16,32, 64 cells per well, n = 8) and cultured in DMEM/F12 (Gibco) supplemented with 1% FBS, 20 ng/mL bFGF and 20 ng/mL EGF for seven days.…”
Section: In Vitro Limiting Dilution Assaymentioning
confidence: 99%
See 1 more Smart Citation
“…Various numbers of Huh7/HepG2 miR-361-3p mimic or miR-361-3p sponge and their control cells were digested and seeded into 96-well ultra-low attachment (2,4,8,16,32, 64 cells per well, n = 8) and cultured in DMEM/F12 (Gibco) supplemented with 1% FBS, 20 ng/mL bFGF and 20 ng/mL EGF for seven days.…”
Section: In Vitro Limiting Dilution Assaymentioning
confidence: 99%
“…T-ICs or CSCs were rst discovered in blood system diseases (6). Later studies also con rmed the existence of T-ICs or CSCs in solid tumors, including breast cancer, liver cancer and glioma (7)(8)(9). Currently researches suggest that T-ICs or CSCs are responsible for the progression, metastasis, recurrence and chemo-resistance of cancers (10)(11)(12).…”
Section: Introductionmentioning
confidence: 99%
“…The OC cells or OC patients' tissues were lysed with cell lysis buffer (Beyotime) followed by supersonic splitting as described previous (13). The total protein was quantified using a BCA Protein…”
Section: Western Blotting Assaysmentioning
confidence: 99%
“…Epithelialmesenchymal transition (EMT) and cancer stem cell (CSC) are typical tumor heterogeneity models and contribute to phenotypic diversity of HCC cells. Stemness and mesenchymal features contributing to primary sorafenib resistance might be acquired at tumor initiation with the help of oncofetal proteins or pathogenic factors [5,6]. Acquired resistance is always established during long-term sorafenib exposure, whereby genomic instability serves as a platform in which random mutations occur in different tumor cells subsequently endowed with different fitness, and sorafenib itself as a selective force favors the outgrowth of drug-resistant subclones.…”
Section: Introductionmentioning
confidence: 99%