2020
DOI: 10.1101/2020.12.15.422853
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Oncogene-induced cardiac neoplasia shares similar mechanisms with heart regeneration in zebrafish

Abstract: The human heart is a poorly regenerative organ and cardiac tumors are extremely rare. The zebrafish heart can restore its damaged myocardium through cardiomyocyte proliferation. Whether this endogenous capacity causes a susceptibility to neoplasia remains unknown. Here, we established a strategy to conditionally express the HRASG12V oncogene in zebrafish cardiomyocytes. The induction of this transgene in larvae or adult animals resulted in heart overgrowth with abnormal histology. The malformed ventricle displ… Show more

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References 115 publications
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