1989
DOI: 10.4267/10608/4042
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Oncogènes et hypertension artérielle

Abstract: Les cellules musculaires lisses de rats atteints d'une hyperten sion spontanée prolifèrent de façon exagérée lors de leur sti mulation par le sérum ou les fa cteurs de croissance. Leur phospholipase C est hyper réactive et l'accumulation de messagers d'oncogènes nucléaires (c-myc, c-fos) est supérieure à celle observée dans · les cellules d'animaux normo tendus. Il se pourrait par consé quent qu'à un niveau ou à un autre certaines hypertensions artérielles génétiques soient liées à une anomalie des voies contr… Show more

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“…Thus, in addition to their role as vasopres sor agents, they may play a role in arterial-wall and car diac hypertrophy associated with hypertension [61]. This action may result from the expression of the c-fos onco gene via transcriptional control [62,63].…”
Section: Angiotensin II Action On Protein Synthesismentioning
confidence: 99%
“…Thus, in addition to their role as vasopres sor agents, they may play a role in arterial-wall and car diac hypertrophy associated with hypertension [61]. This action may result from the expression of the c-fos onco gene via transcriptional control [62,63].…”
Section: Angiotensin II Action On Protein Synthesismentioning
confidence: 99%