Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas

Barros-Filho, Mateus Camargo; Reis-Rosa, L.A.; Hatakeyama, Márcia; Marchi, Fábio Albuquerque; Chulam, Thiago Celestino; Scapulatempo-Neto, C.; Nicolau, Ulisses Ribaldo; Carvalho, André L.; Pinto, Clóvis Antônio Lopes; Drigo, Sandra A.; Kowalski, Luiz Paulo; Rogatto, Sílvia Regina

doi:10.1016/j.oraloncology.2018.06.010

Cited by 23 publications

(18 citation statements)

References 59 publications

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“…Analysis of datasets from Oncomine, GEPIA and GEO con rmed that PPFIA1 mRNA expression was markedly higher in ESCC tissues than in adjacent normal control tissues, which was further con rmed with cDNA array data based on qRT-PCR and TMA data based on IHC. These results indicated that PPFIA1 may play a vital role during the tumorigenesis of ESCC, which was consistent with the results discovered in other malignant tumors [19,22]. Further correlation analysis revealed that PPFIA1 expression is highly correlated with aggressive biological behaviors of tumors, indicating the important function of PPFIA1 in the progression of ESCC.…”

Section: Discussionsupporting

confidence: 90%

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor progression and poor prognosis

Tang

Jia

Gong

et al. 2022

Preprint

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We aimed to investigate the expression and clinical value of PTPRF interacting protein alpha 1 (PPFIA1) in esophageal squamous cell carcinoma (ESCC). The Oncomine, GEPIA, and GEO databases were utilized to explore PPFIA1 mRNA expression in esophageal cancer. The associations of PPFIA1 expression with clinicopathological variables and prognosis were evaluated in the GSE53625 dataset and verified in qRT-PCR-based cDNA array and immunohistochemistry-based tissue microarray (TMA) datasets. The interactions between PPFIA1 and other genes based on the protein-protein interaction (PPI) network was analyzed via the STRING website. We found PPFIA1 expression was obviously upregulated in ESCC tissues versus adjacent normal tissues according to online database analyses (P<0.05). High PPFIA1 expression was significantly associated with several clinicopathological features, including tumor size, histological grade, tumor invasion depth, lymph node metastasis, and TNM stage. High PPFIA1 expression was related to worse outcomes and was identified as an independent prognostic indicator of overall survival in ESCC patients (GSE53625 dataset, P=0.004; cDNA array dataset, P<0.001; TMA dataset, P=0.039). PPI analysis demonstrated that PPFIA1 was highly correlated with multiple genes, including UNC13B, RAB3A, PTPRD, and SYT1. In conclusion, PPFIA1 may be associated with ESCC progression and could be used as a biomarker for prognostic evaluation in ESCC patients.

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Section: Discussionsupporting

confidence: 90%

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor progression and poor prognosis

Tang

Jia

Gong

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Analysis of datasets from Oncomine, GEPIA and GEO con rmed that PPFIA1 mRNA expression was markedly higher in ESCC tissues than in adjacent normal control tissues, which was further con rmed with cDNA array data based on qRT-PCR and TMA data based on IHC. These results indicated that PPFIA1 may play a vital role during the tumorigenesis of ESCC, which was consistent with the results discovered in other malignant tumors [17,20]. Further correlation analysis revealed that PPFIA1 expression is highly correlated with aggressive biological behaviors of tumors, indicating the important function of PPFIA1 in the progression of ESCC.…”

Section: Discussionsupporting

confidence: 90%

High Expression of PPFIA1 Is Associated With Tumor Progression and a Poor Prognosis in Esophageal Squamous Cell Carcinoma

Zhang

Jia

Yang

et al. 2021

Preprint

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Background: PTPRF interacting protein alpha 1 (PPFIA1) is reportedly related to the occurrence and progression of several types of malignancies. However, its role in esophageal squamous cell carcinoma (ESCC) remains unknown. We aimed to investigate the expression and clinical value of PPFIA1 in ESCC.Methods: The Oncomine, Gene Expression Profiling Enrichment Analysis (GEPIA), and Gene Expression Omnibus (GEO) databases were utilized to explore PPFIA1 mRNA expression in esophageal cancer. The associations of PPFIA1 expression with clinicopathological variables and prognosis were evaluated in the GSE53625 dataset and verified in quantitative real-time polymerase chain reaction (qRT-PCR)-based cDNA array and immunohistochemistry (IHC)-based tissue microarray (TMA) datasets. The interactions between PPFIA1 and other genes based on the protein-protein interaction (PPI) network was analyzed via the STRING website.Results: PPFIA1 expression was obviously upregulated in ESCC tissues versus adjacent normal tissues according to online database analyses (all P<0.05). High PPFIA1 expression was significantly associated with several clinicopathological features, including tumor size, histological grade, tumor invasion depth, lymph node metastasis, and tumor-node-metastasis (TNM) stage. High PPFIA1 expression was related to worse outcomes and was identified as an independent prognostic indicator of overall survival (OS) in ESCC patients GSE53625 dataset, P=0.004; cDNA array dataset, P<0.001; TMA dataset, P=0.039). PPI analysis demonstrated that PPFIA1 was highly correlated with multiple genes, including UNC13B, RAB3A, PTPRD, and SYT1.Conclusion: PPFIA1 may be associated with ESCC progression and could be used as a biomarker for prognostic evaluation in ESCC patients.

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“…Nevertheless, given the size of the 11q13 amplicon, it cannot be ruled out that the overexpression of these genes may be secondary and that other genes within the 11q13 amplicon could act as true drivers of HNSCC progression. A recent study has also identified four genes ( ORAOV1 , CPT1A , SHANK2 and PPFIA1 ) as important drivers of 11q13 amplification that showed an impact on prognosis [28]. Therefore, various genes within the 11q13 amplicon could cooperatively contribute to the differences in prognosis and clinical outcome between HPV-positive and HPV-negative tumors.…”

Section: Discussionmentioning

confidence: 99%

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients

Hermida-Prado

Menéndez

Albornoz-Afanasiev

et al. 2018

JCM

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Clear differences have been established between head and neck squamous cell carcinomas (HNSCC) depending on human papillomavirus (HPV) infection status. This study specifically investigated the status of the CTTN, CCND1 and ANO1 genes mapping at the 11q13 amplicon in relation to the HPV status in HNSCC patients. CTTN, CCND1 and ANO1 protein expression and gene amplification were respectively analyzed by immunohistochemistry and real-time PCR in a homogeneous cohort of 392 surgically treated HNSCC patients. The results were further confirmed using an independent cohort of 279 HNSCC patients from The Cancer Genome Atlas (TCGA). The impact on patient survival was also evaluated. CTTN, CCND1 and ANO1 gene amplification and protein expression were frequent in HPV-negative tumors, while absent or rare in HPV-positive tumors. Using an independent validation cohort of 279 HNSCC patients, we consistently found that these three genes were frequently co-amplified (28%) and overexpressed (39–46%) in HPV-negative tumors, whereas almost absent in HPV-positive tumors. Remarkably, these alterations (in particular CTTN and ANO1 overexpression) were associated with poor prognosis. Taken together, the distinctive expression and amplification of these genes could cooperatively contribute to the differences in prognosis and clinical outcome between HPV-positive and HPV-negative tumors. These findings could serve as the basis to design more personalized therapeutic strategies for HNSCC patients.

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Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas

Abstract: The integrative genomic and transcriptomic data revealed potential driver genes mapped in 11q13 associated with worse prognosis and response to treatment, giving fundamentals for the identification of novel therapeutic targets in OPSCC.

Cited by 23 publications

References 59 publications

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor progression and poor prognosis

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor progression and poor prognosis

High Expression of PPFIA1 Is Associated With Tumor Progression and a Poor Prognosis in Esophageal Squamous Cell Carcinoma

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients

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