Oncogenic evaluation of tetrachlorvinphos in the B6C3F1 mouse

Parker, C. M.; Gelder, G. A. Van; Chai, Eric Y.; Gellatly, J.B.M.; Serota, David G.; Voelker, R.; Vesselinovitch, S. D.

doi:10.1016/0272-0590(85)90167-8

Cited by 11 publications

(2 citation statements)

References 31 publications

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“…The relationship between exposure to many pesticides and the occurrence of cancer in animal and in vitro studies is well established; it is often summarized in the IARC monographs, for instance. 11 , 40 , 136 , 138 , 139 , 140 In the primary human studies we reviewed here, there is modest coherence, partly due to the difficulties with exposure imprecision. A major conclusion of this article is that newer, biomonitoring‐based designs can resolve some of the issues with coherence in the literature.…”

Section: Discussionmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia (AML) and colorectal cancer (CRC), diseases in which the observed associations were consistent across several studies, including high‐quality prospective studies and those using biomarkers for exposure assessment, with some observing dose‐response relationships. Though high‐quality studies have been published since the IARC monograph on organophosphate insecticides in 2017, there are still gaps in the literature on carcinogenic evidence in humans for a large number of pesticides. To further knowledge, we suggest leveraging new techniques and methods to increase sensitivity and precision of exposure assessment, incorporate multi‐omics data, and investigate more thoroughly exposure to chemical mixtures. There is also a strong need for better and larger population‐based cohort studies that include younger and nonoccupationally exposed individuals, particularly during developmental periods of susceptibility. Though the existing evidence has limitations, as always in science, there is sufficient evidence to implement policies and regulatory action that limit pesticide exposure in humans and, hence, further prevent a significant burden of cancers.

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Section: Discussionmentioning

confidence: 99%

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Cavalier

Trasande

Porta

2022

Intl Journal of Cancer

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“…The study design generally includes 1 or 2 control groups and 3-4 treated groups as well as animals assigned to interim sacrifice groups. An example of the experimental design for a typical chronic toxicity/carcinogenicity study (14) is presented in Table IV. For chronic toxicity/carcinogenicity studies, the technical approach should assure that all neoplasms and related proliferative changes have been identified and appropriately classified, that potential target organs have been identified, that treatment-related changes have been consistently and accurately characterized, and that the NOEL has been identified (Table V) ( 16,21 ) and PWG-type reviews (5,9,15,20,25). The findings in these reviews fall into a few categories including evolution of terminology (5), extreme differences in opinion (9,16), and disagreements in terminology or classification of lesions (12,15,17,21,25).…”

Section: Introductionmentioning

confidence: 99%

Peer Review in Toxicologic Pathology

et al. 1995

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Peer review of histopathology findings in safety assessment studies involving rodents and other animals is a relatively recent procedure in toxicologic pathology. It serves to ensure the integrity of the pathology evaluation in safety studies, encourages consistency of diagnostic criteria and use of common terminology, and provides a method of continuing education for participants. The use of a standardized system of pathology nomenclature and diagnostic criteria, such as the Society of Toxicologic Pathologist's Guides for Toxicologic Pathology, is of great value in the procedure. Pathology reviews may involve government-sponsored bioassay programs, in-house industrial corporations, or individual peer reviews suggested or required by government regulatory agencies. Pathology Working Groups can be an integral part of the review process. The extent of the peer review is primarily dependent on the study results; however, other variables such as confidence of the data, study size and duration, complexity, and purpose are also important considerations. Essential components of any peer review, however, include selection of tissues/lesions for review, by a reviewing pathologist, discrepancy resolution, data modification, and documentation of all aspects of the review process. Specific procedures for pathology peer review are discussed. Disagreements among pathologists discovered in peer reviews can be resolved by several methods and examples will be presented. The entire pathology peer review process should be a learning experience for all involved and can help ensure the integrity of animal toxicology studies used for important regulatory decisions involving the use of chemicals in our society.

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Toxicologic Units

Yermakoff¹

1987

Toxic Substances and Human Risk

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Oncogenic evaluation of tetrachlorvinphos in the B6C3F1 mouse

Cited by 11 publications

References 31 publications

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

Peer Review in Toxicologic Pathology

Toxicologic Units

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