Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis

Won, Yoonkyung; Jang, Bogun; Lee, Su-Hyung; Reyzer, Michelle L.; Presentation, Kimberly S.; Kim, Hyesung; Caldwell, Brianna; Zhang, Changqing; Lee, Hye Seung; Lee, Cheol; Trinh, Vincent Q.; Tan, Marcus C.B.; Kim, Kwangho; Caprioli, Richard M.; Choi, Eunyoung

doi:10.1053/j.gastro.2024.01.027

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…Recently, knock in of Kras G12D alone in zymogen-secreting chief cells has been reported to lead to the development of precancerous metaplasia and high-grade dysplasia. Metabolic rewiring from glycolysis to fatty acid metabolism occurs during the progression from metaplasia to dysplasia 118 . Stearoyl-coenzyme A desaturase dependent production of monounsaturated fatty acids fuels dysplastic cells 118 .…”

Section: Genetically Engineered Gc Mouse Modelsmentioning

confidence: 99%

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Modeling human gastric cancers in immunocompetent mice

Zhang,

Wang,

Zhang

et al. 2024

Cancer Biol Med

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Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. This cancer is determined by multiple (epi)genetic and environmental factors; can occur at distinct anatomic positions of the stomach; and displays high heterogeneity, with different cellular origins and diverse histological and molecular features. This heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient therapeutics. In the past decade, great progress has been made in the study of GC, particularly in molecular subtyping, investigation of the immune microenvironment, and defining the evolutionary path and dynamics. Preclinical mouse models, particularly immunocompetent models that mimic the cellular and molecular features of human GC, in combination with organoid culture and clinical studies, have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion, and the development of novel therapeutic strategies. Herein, we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models, emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies.

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Section: Genetically Engineered Gc Mouse Modelsmentioning

confidence: 99%

“…Metabolic rewiring from glycolysis to fatty acid metabolism occurs during the progression from metaplasia to dysplasia 118 . Stearoyl-coenzyme A desaturase dependent production of monounsaturated fatty acids fuels dysplastic cells 118 .…”

Section: Genetically Engineered Gc Mouse Modelsmentioning

confidence: 99%

Modeling human gastric cancers in immunocompetent mice

Zhang,

Wang,

Zhang

et al. 2024

Cancer Biol Med

View full text Add to dashboard Cite

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Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy

Sun,

Liu,

Chen

et al. 2024

Annals of Medicine

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Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

Zhang,

Zhao,

et al. 2024

Front. Cardiovasc. Med.

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Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct of glycolysis, is now acknowledged for its crucial role in the cellular functions of the cardiovascular system. Recent studies have shown that lactate influences the proliferation, differentiation, and activation of immune cells through its modulation of post-translational protein modifications, thereby affecting the development and prognosis of cardiovascular disease. Consequently, there has been a notable increase in interest towards drug targets targeting lactylation in immune cells, prompting further exploration. In light of the swift advancements in this domain, this review article is dedicated to examining lactylation in cardiovascular disease and potential drug targets for regulating lactylation, with the aim of enhancing comprehension of this intricate field.

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Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis

Cited by 3 publications

References 54 publications

Modeling human gastric cancers in immunocompetent mice

Modeling human gastric cancers in immunocompetent mice

Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy

Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

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