Oncogenic hypophosphatemic osteomalacia

Agus, Zalman S.

doi:10.1038/ki.1983.133

Cited by 55 publications

(12 citation statements)

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“…Other findings associated with proximal tubular dysfunction such as hyperuricosuria or impaired urinary acidification have not been found. Serum levels ofparathyroid hormone, calcium and 25-OH vitamin D are normal whereas the 1,25-(OH)2D3 level is uniformly low (Agus, 1983a;Drezner et al, 1982;Drezner and Feinglos, 1977;Fukumoto et al, 1979;Lau et al, 1979;Sweet et al, 1980). Complete resolution of the clinical and metabolic abnormalities occurs upon removal of the tumour.…”

Section: Discussionmentioning

confidence: 99%

“…Since then, at least 32 additional reports have described a similar clinical entity completely cured by tumour removal, a syndrome now referred to as oncogenic osteomalacia (Agus, 1983a;Fukumoto et al, 1979;Weidner et al, in press). Patients with oncogenic osteomalacia characteristically present with a low renal threshold for phosphate reabsorption (TmPO4/GFR) (Walton & Bijvoet, 1975), hypophosphataemia, and osteomalacia.…”

Section: Introductionmentioning

confidence: 99%

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Oncogenic osteomalacia: strange tumours in strange places

Weiss

Bar

Weidner

et al. 1985

Postgraduate Medical Journal

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Summary:Two patients presented with hypophosphataemic osteomalacia and were subsequently found to have small tumours of unusual histopathology and location causing the osteomalacia. Each tumour was found after an intensive search for occult masses. Studies of vitamin D metabolism and renal tubular function before and after surgery yielded further insight into the pathophysiology of oncogenic osteomalacia. These cases demonstrate that microscopic quantities of tumour are capable of causing the syndrome and further illustrate the high index of suspicion often necessary to locate causative tumours in patients with hypophosphataemic osteomalacia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oncogenic osteomalacia: strange tumours in strange places

Weiss

Bar

Weidner

et al. 1985

Postgraduate Medical Journal

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“…Renal action of OHO tumour factors OHO tumour extracts and conditioned medium derived from cultured OHO tumours specifically inhibit Na/Pi cotransport in cultured renal proximal tubular cells [2,12,33,37,54,61,87]. However, it is not clear whether this inhibition involves the down-regulation of Npt2 or is secondary to metabolic changes.…”

Section: Treatment Of Adhrmentioning

confidence: 95%

Novel phosphate-regulating genes in the pathogenesis of renal phosphate wasting disorders

Tenenhouse

Sabbagh

2002

Pflügers Arch - Eur J Physiol

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Over the past decade, three classes of Na/Pi cotransporters have been identified in mammalian kidney. The type IIa Na/Pi cotransporter, Npt2, is the most abundant and is expressed in the brush-border membrane of renal proximal tubular cells where the bulk of filtered inorganic phosphate (Pi) is reabsorbed. Disruption of the Npt2 gene in mice underscored the importance of Npt2 in the overall maintenance of Pi homeostasis and demonstrated that Npt2 is the target for regulation of proximal tubular Pi reabsorption by parathyroid hormone and dietary Pi. The regulation is post-transcriptional and largely occurs by brush-border membrane retrieval and insertion of Npt2 protein. Of great interest is the recent identification of novel Pi regulating genes, PHEX and FGF23, that play a role in the pathophysiology of inherited (X-linked hypophosphatemia and autosomal dominant hypophosphatemic rickets) and acquired (oncogenic hypophosphatemic rickets) disorders characterized by renal Pi wasting and associated skeletal abnormalities. Studies are currently underway to elucidate the molecular basis for impaired renal Pi reabsorption in these disorders and to determine the precise physiological role of PHEX and FGF-23 in the regulation of Pi homeostasis.

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“…Benign mesenchymal neoplasm [II], prostatic carcinoma [12], breast carcinoma and the epidermal ne vus syndrome [13] have been associated with phosphate diabetes. Recently, a case of renal hypophosphatemia associated with an SIADH has been reported [1[.…”

Section: Discussionmentioning

confidence: 99%