Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma

Toraih, Eman A.; Ellawindy, Alia; Salma, Yahya; Ageeli, Essam Al; Gouda, Nawal S.; Fawzy, Manal S.; Hosny, Somaya

doi:10.1016/j.biopha.2018.03.105

Cited by 48 publications

(43 citation statements)

References 77 publications

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“…LncRNAs are emerging as key players in cancer formation and development. MALAT1, also known as nuclearenriched transcript 2, is the most well-known lncRNA that plays an important role in the pathogenesis and progression of different tumors (51)(52)(53)(54)(55)(56). Elevated expression of MALAT1 promotes cell proliferation, invasion, migration, and metastasis in OC.…”

Section: Discussionmentioning

confidence: 99%

miR‐211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma

et al. 2018

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Accumulating evidence has indicated that microRNAs (miRNAs) play an important role in the occurrence and progression of ovarian cancer (OC). However, the function of miRNAs implicated in OC remains unclear. This study investigated the potential role of miR-211 in OC. Gene Expression Omnibus database analysis indicated that miR-211 expression was significantly down-regulated in OC tissues compared with normal specimens. In addition, miR-211 overexpression apparently inhibited proliferation, migration, xenograft growth, and induced apoptosis in HEY-T30 and SKOV3 cells. Moreover, PHF19, a component of the polycomb group of proteins, was found to be a direct target of miR-211 based on the luciferase reporter assay and Western blot analysis. Consistently, survival analysis indicated that high PHF19 expression was associated with shorter survival time in patients with OC. Importantly, silence of PHF19 reduced proliferation, induced cell cycle arrest, promoted apoptosis, suppressed migration, and inhibited xenograft growth in SKOV3 cells. Restoration of PHF19 expression markedly reversed the inhibitory effect of miR-211 on OC. Moreover, our results indicate that the long noncoding RNA MALAT1 could sponge miR-211 as a competing endogenous RNA and potentially up-regulate PHF19 expression, thus facilitating the OC progression. These findings suggest that the MALAT1/miR-211/PHF19 axis may act as a key mediator in OC and provide new insight into the prevention of this disease.-Tao, F., Tian, X., Ruan, S., Shen, M., Zhang, Z. miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma.

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Section: Discussionmentioning

confidence: 99%

miR‐211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma

et al. 2018

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“…***P < 0.001 vs control group, ## P < 0.01 vs vehicle + FPI group hepatocellular carcinoma. 26 High expression of Malat1 is associated with a poor prognosis and promotes clinical progression and metastasis in bladder cancer. 27 Malat1 may be utilized for the treatment of diabetes caused by excessive exposure to reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of long noncoding RNA Malat1 ameliorates traumatic brain injury induced brain edema by inhibiting AQP4 and the NF‐κB/IL‐6 pathway

Zhang

Wang

Zhang

et al. 2019

J of Cellular Biochemistry

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Brain edema is a major traumatic brain injury (TBI)‐related neurological complication. In the initiation stage of TBI, brain edema is characterized by astrocyte swelling (cytotoxic edema). We studied the impact of a long noncoding RNA, Malat1, on the TBI‐induced astrocyte swelling and brain edema. Our results showed that Malat1 was downregulated in both the TBI rat model and the astrocyte fluid percussion injury (FPI) model, which concurred with brain edema and astrocyte swelling. Overexpression of Malat1 significantly inhibited rat brain edema, meanwhile reducing interleukin‐6 (IL‐6), nuclear factor‐κB (NF‐κB), and aquaporin 4 (AQP4) expression after TBI. In addition, overexpression of Malat1 ameliorated FPI‐induced astrocyte swelling and reduced IL‐6 release. Quantitative real‐time polymerase chain reaction and Western blot analysis also corroborated the inhibitory effects of Malat1 on NF‐κB and AQP4 expression after FPI. Our results highlighted the protective effects of Malat1 on the TBI‐induced brain edema, which were mediated through regulating IL‐6, NF‐κB, and AQP4 expression. Our study could provide a novel approach for TBI treatment.

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“…Yuan et al [40] reported that the plasma levels of LINC00152, RP11-160H22.5, and XLOC_014172 could effectively distinguish patients with HCC from chronic hepatitis patients and healthy controls. Another study also showed that serum levels of MALAT1 could differentiate HCC patients from HCV-induced liver cirrhosis patients and healthy controls [41].…”

Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 96%

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Kim

Park

Lee

2020

IJMS

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Long non-coding RNAs (lncRNAs) are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including hepatocellular carcinoma (HCC). However, the involvement of these molecules in chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and viral hepatitis, has only recently been considered in scientific research. While extensive studies on the pathogenesis of the development of HCC from hepatic fibrosis have been conducted, their regulatory molecular mechanisms are still only partially understood. The underlying mechanisms related to lncRNAs leading to HCC from chronic liver diseases and cirrhosis have not yet been entirely elucidated. Therefore, elucidating the functional roles of lncRNAs in chronic liver disease and HCC can contribute to a better understanding of the molecular mechanisms, and may help in developing novel diagnostic biomarkers and therapeutic targets for HCC, as well as in preventing the progression of chronic liver disease to HCC. Here, we comprehensively review and briefly summarize some lncRNAs that participate in both hepatic fibrosis and HCC.

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Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma

Cited by 48 publications

References 77 publications

miR‐211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma

miR‐211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma

Overexpression of long noncoding RNA Malat1 ameliorates traumatic brain injury induced brain edema by inhibiting AQP4 and the NF‐κB/IL‐6 pathway

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

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