Oncogenic MORC2 in cancer development and beyond

Zhang, Shan; Guo, Ayao; Wang, Huan; Liu, Jia; Dong, Chengliang; Ren, Junyi; Wang, Guiling

doi:10.1016/j.gendis.2023.05.010

Cited by 7 publications

(3 citation statements)

References 118 publications

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“…MORC2 expression is very high in cancer cells compared to normal cells [18]. Several cancers, including breast, lung, liver, prostate, stomach, colon, ovarian, pancreatic, and endometrial, have dysregulated MORC2 expression [57,58]. This increased expression of MORC2 is linked to cancer cell proliferation, metabolism, invasion, migration, and metastasis and confers chemotherapy resistance [15,[23][24][25]35,42,46,55,[57][58][59][60][61][62][63][64].…”

Section: Morc2 Role In Cancermentioning

confidence: 99%

“…Several cancers, including breast, lung, liver, prostate, stomach, colon, ovarian, pancreatic, and endometrial, have dysregulated MORC2 expression [57,58]. This increased expression of MORC2 is linked to cancer cell proliferation, metabolism, invasion, migration, and metastasis and confers chemotherapy resistance [15,[23][24][25]35,42,46,55,[57][58][59][60][61][62][63][64]. Furthermore, increased MORC2 expression levels were linked to poor prognosis and unfavorable clinical outcomes in non-small cell lung and breast cancer [58].…”

Section: Morc2 Role In Cancermentioning

confidence: 99%

“…Furthermore, increased MORC2 expression levels were linked to poor prognosis and unfavorable clinical outcomes in non-small cell lung and breast cancer [58]. Notably, MORC2 interacts with many proteins to control the expression of its downstream targets, which promote the hallmarks of cancer or directly modulate the hallmarks of cancer by regulating the transcription of its target genes [15,57].…”

Section: Morc2 Role In Cancermentioning

confidence: 99%

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Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer

Chutani,

Ragula,

Syed

et al. 2023

Biomolecules

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A newly discovered chromatin remodeler, MORC2, is a Microrchidia (MORC) family member. MORC2 acts as a chromatin remodeler by binding to the DNA and changing chromatin conformation using its ATPase domain. MORC2 is highly expressed in a variety of human cancers. It controls diverse signaling pathways essential for cancer development through its target genes and interacting partners. MORC2 promotes cancer cells’ growth, invasion, and migration by regulating the expression of genes involved in these processes. MORC2 is localized primarily in the nucleus and is also found in the cytoplasm. In the cytoplasm, MORC2 interacts with adenosine triphosphate (ATP)-citrate lyase (ACLY) to promote lipogenesis and cholesterogenesis in cancer. In the nucleus, MORC2 interacts with the transcription factor c-Myc to control the transcription of genes involved in glucose metabolism to drive cancer cell migration and invasion. Furthermore, MORC2 recruits on to the promoters of tumor suppressor genes to repress their transcription and expression to promote oncogenesis. In addition to its crucial function in oncogenesis, it plays a vital role in DNA repair. Overall, this review concisely summarizes the current knowledge about MORC2-regulated molecular pathways involved in cancer.

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