Oncogenic viral DNA related to human breast cancer found on cattle milk and meat

de Quadros, Daniel Lazzari; Ribeiro, Vitoria Agnoletto; Rezende, Mariana Antunes; Maté, Yasmin Ampese; Gomes, Márcio Alexandro; Secchi, Katia; Strottmann, Daisy Maria; Frandoloso, Rafael; Kreutz, Luiz Carlos

doi:10.1016/j.cimid.2023.102053

Cited by 2 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A lack of protein mRNA expression leads to severe autoimmune diseases and significant tissue damage in many organs (Sutherland et al 2000;Homann et al 2006). Various nucleotide substitutions in CTLA-4 gene mapped to human chromosome 2q33 have been associated with susceptibility to various autoimmune and infectious diseases mediated by T cells (Danilovic et al 2012;Liu et al 2013). According to Eskandari-Nasab et al (2014), the CTLA-4 gene C/T polymorphism at position 318 in the Iranian population indicated susceptibility to the risk of brucellosis infection.…”

Section: Structure and Function Of Ctla-4mentioning

confidence: 99%

“…This receptor was the first immune checkpoint that has become a clinical target for cancer immunotherapy. Monoclonal antibodies against CTLA-4 blocking the CTLA-4-CD80/CD86 signaling pathway activate antitumor immunity and improve the survival of patients with melanoma (Danilovic et al 2012). One signaling pathway that enhances T-cell activity is the interaction of the CD28 receptor with CD80 and CD86, which significantly enhances the TCR-antigen signaling.…”

Section: Structure and Function Of Ctla-4mentioning

confidence: 99%

See 1 more Smart Citation

Role of Programmed Cell Death Receptor-1 and Cytotoxic T Lymphocyte-Associated Antigen 4 in Bovine Leukemia Virus Infection

2023

Int J Vet Sci

View full text Add to dashboard Cite

A cluster of T-cell receptors includes activating and inhibitory stimulatory molecules that favorably or unfavorably control immune responses. Recent studies on chronic bovine infections have revealed that, under severe viral loads and malignant pathologies, stromal and immune cells increase the expression of immune inhibitory molecules. To maintain internal homeostasis, programmed cell death receptor-1 (PD-1) and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibit T cell activity. In chronic viral infections, the prolonged activation of T cells leads to the continuous production of PD-1 and CTLA-4. Blocking PD-1 and CTLA-4 is a successful therapeutic approach that is actively used in the treatment of oncological diseases. The effectiveness of this approach in the treatment of chronic viral infections, particularly those caused by bovine leukemia virus has been hypothesized. However, uncertainty surrounds these receptors' function in persistent viral infections. This review focused on the functions of PD-1 and CTLA-4 in bovine leukemia virus and discusses disease therapies based on their blockade.

show abstract