Oncologic and Long-Term Outcomes of Laparoscopic and Open Extended Cholecystectomy for Gallbladder Cancer

Lee, Jong Woo; Kwon, Jae‐Hyun; Lee, Jung Woo

doi:10.3390/jcm11082132

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…17 For a considerable amount of time, laparoscopic surgery has been deemed inappropriate for GBC, mostly due to technical difficulties; additional reasons include the possibility of pneumoperitoneum spreading the disease and the increased risk of spreading in the event of bile leakage. 18 In this review, the complications rate of laparoscopic surgery was similar with open surgery, including bile leakage and pneumoperitoneum. The morbidity (10.0%) and mortality (0.0%) rates in the laparoscopic group seemed to be acceptable and not inferior to those in the open group.…”

Section: Discussionmentioning

confidence: 78%

“…The morbidity (10.0%) and mortality (0.0%) rates in the laparoscopic group seemed to be acceptable and not inferior to those in the open group. 18 More research has been done on laparoscopic surgery for GBC in the past several years. The use of laparoscopic surgery for GBC is supported by current research due to advancements in high-definition display technology, surgical equipment refinement, and surgeon progress.…”

Section: Discussionmentioning

confidence: 99%

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The Systematic Review of Open Versus Laparoscopic Surgery in the Management of Patients With Gallbladder Cancer

Ade Ansari,

Putri Handayani,

Febriana

et al. 2024

JARMHS

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Background: Gallbladder cancer (GBC) is a rare highly aggressive disease with a global prevalence of 2/100000 people, with women being 2-3 times more likely than men. Management requires a multimodal strategy, with surgery being the gold standard for curative intent. Nowadays, treating common gastrointestinal cancers with laparoscopic techniques is commonly recognized. However, there is still debate on the laparoscopic method for treating GBC. The aim: This study aims to show the differences between open and laparoscopic surgery for gallbladder cancer. Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like PubMed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Results: In the PubMed database, the results of our search brought up 22 articles, whereas the results of our search on ScienceDirect brought up 85 articles. The results of the search conducted by title screening yielded a total 17 articles for PubMed and 12 articles for ScienceDirect. We compiled a total of 22 papers, 11 of which came from PubMed and 11 of which came from ScienceDirect. We excluded 3 review articles, 4 duplicate articles, 4 non-full text articles, 2 articles having ineligible subjects, and 1 article having insufficient outcomes. In the end, we included eight research that met the criteria. Conclusion: The outcomes of laparoscopic and open surgery in the management of gallbladder cancer are comparable in terms of post-operative complications, recurrence rates, survival rates, and disease free survival rates. However, laparoscopic approach shows benefit on length of hospital stay

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

The Systematic Review of Open Versus Laparoscopic Surgery in the Management of Patients With Gallbladder Cancer

Ade Ansari,

Putri Handayani,

Febriana

et al. 2024

JARMHS

View full text Add to dashboard Cite

show abstract

“…The use of laparoscopic surgery for GBC is increasing owing to favorable postoperative outcomes and development of surgeon's skill 17 . A series of reports claimed less postoperative pain, early recovery, and superior cosmetic results in L‐EC, with oncological outcomes comparable to those of O‐EC 5,7,9,18–20 . As a result, concerns such as tumor cell spillage, technical safety of laparoscopic resection, and LND have been mostly resolved.…”

Section: Discussionmentioning

confidence: 99%

“…17 A series of reports claimed less postoperative pain, early recovery, and superior cosmetic results in L-EC, with oncological outcomes comparable to those of O-EC. 5,7,9,[18][19][20] As a result, concerns such as tumor cell spillage, technical safety of laparoscopic resection, and LND have been mostly resolved.…”

Section: Univariate Analysis Multivariate Analysis Hr (95% Ci) P-valu...mentioning

confidence: 99%

Clinical outcomes of minimally invasive (laparoscopic and robotic) versus open extended cholecystectomy: A multicenter propensity score matched study

Sohn,

Lee,

Han

et al. 2024

J Hepato Biliary Pancreat

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BackgroundThis multicenter study aimed to compare the clinical outcomes of minimally invasive extended cholecystectomy (MI‐EC) versus open EC (O‐EC) for patients with gallbladder cancer (GBC).MethodsPatients who underwent EC (cholecystectomy, wedge resection of the liver bed, and regional lymphadenectomy) for GBC between 2010 and 2020 in three centers were included in the study. The clinicopathological data were compared after propensity score matching. Additional subgroup analysis on laparoscopic and robotic EC (L‐EC and R‐EC) was performed.ResultsA total of 377 patients were included: 308 for O‐EC and 69 for MI‐EC, respectively. The MI‐EC group had a longer operative time (188.9 vs. 238.1 min, p < .001) and shorter hospital stay (9.0 vs. 7.2 days, p = .007), although no differences were found in operative blood loss, complication rate and survival outcome. In subgroup analysis, L‐EC patients had a longer operative time (264.4 vs. 202.0 min, p = .001), compared to R‐EC patients with comparable perioperative and survival outcomes.ConclusionAlthough patients with MI‐EC had a longer operation time and higher medical costs, the advantages were enhanced recovery with comparable short‐ and long‐term outcomes. The operation time was less for R‐EC patients than for L‐EC patients, though the high cost still remains. The surgery type for EC can be selected according to the patient's condition, social status and surgeon's preference.

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“…While surgery is the most effective treatment for GBC, early diagnosis is rare. Most patients lack the option of surgery upon diagnosis, and local recurrence following both laparoscopic and open surgery is >9% 10. For many individuals who receive successful surgical treatment, GBC was accidentally discovered during other operations 11,12…”

mentioning

confidence: 99%

Update on Chemoresistance Mechanisms to First-Line Chemotherapy for Gallbladder Cancer and Potential Reversal Strategies

Lai

Yang

Lin

et al. 2023

American Journal of Clinical Oncology

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Objective: Gallbladder cancer (GBC) mortality remains high and chemoresistance is increasing. This review consolidates what is known about the mechanisms of chemoresistance to inform and accelerate the development of novel GBC-specific chemotherapies.Methods: Studies related to GBC-related chemoresistance were systematically screened in PubMed using the advanced search function. Search terms included GBC, chemotherapy, and signaling pathway.Results: Analysis of existing studies showed that GBC has poor sensitivity to cisplatin, gemcitabine (GEM), and 5-fluorouracil. DNA damage repair-related proteins, including CHK1, V-SCR, and H2AX, are involved in tumor adaptation to drugs. GBC-specific chemoresistance is often accompanied by changes in the apoptosis and autophagy-related molecules, BCL-2, CRT, and GBCDRlnc1. CD44 + and CD133 + GBC cells are less resistant to GEM, indicating that tumor stem cells are also involved in chemoresistance. In addition, glucose metabolism, fat synthesis, and glutathione metabolism can influence the development of drug resistance. Finally, chemosensitizers such as lovastatin, tamoxifen, chloroquine, and verapamil are able improve the therapeutic effect of cisplatin or GEM in GBC.Conclusions: This review summarizes recent experimental and clinical studies of the molecular mechanisms of chemoresistance, including autophagy, DNA damage, tumor stem cells, mitochondrial function, and metabolism, in GBC. Information on potential chemosensitizers is also discussed. The proposed strategies to reverse chemoresistance should inform the clinical use of chemosensitizers and gene-based targeted therapy for this disease.

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Oncologic and Long-Term Outcomes of Laparoscopic and Open Extended Cholecystectomy for Gallbladder Cancer

Cited by 7 publications

References 23 publications

The Systematic Review of Open Versus Laparoscopic Surgery in the Management of Patients With Gallbladder Cancer

The Systematic Review of Open Versus Laparoscopic Surgery in the Management of Patients With Gallbladder Cancer

Clinical outcomes of minimally invasive (laparoscopic and robotic) versus open extended cholecystectomy: A multicenter propensity score matched study

Update on Chemoresistance Mechanisms to First-Line Chemotherapy for Gallbladder Cancer and Potential Reversal Strategies

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