Oncologic Outcome and Urinary Function after Radical Cystectomy for Rhabdomyosarcoma in Children: Role of the Orthotopic Ileal Neobladder Based on 15-Year Experience at a Single Center

Castagnetti, Marco; Angelini, Lorenzo; Alaggio, Rita; Scarzello, Giovanni; Bisogno, Gianni; Rigamonti, Waifro

doi:10.1016/j.juro.2013.12.040

Cited by 16 publications

(17 citation statements)

References 14 publications

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“…In our daily clinical practice, we tended to carry out salvage chemotherapy and/or radiotherapy for patients with positive surgical margins; just three patients with positive surgical margins underwent re‐operation of residual tumor resection. In the context of palliation, surgery can relieve symptoms (severe hematuria, urinary or bowel obstruction) to improve quality of life, such as palliative urinary and/or stool diversion …”

Section: Discussionmentioning

confidence: 99%

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Wang

Tan

et al. 2017

Int J of Urology

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Abbreviations & Acronyms B = bladder HR = hazard ratio K = kidney LRFS = local recurrence-free survival MFS = metastasis-free survival NR = not reported OS = overall survival P = paratesticular RMS = rhabdomyosarcoma Objectives: To report our institutional experience in the management of adult genitourinary sarcoma. Methods: This was a retrospective analysis of data on adult genitourinary sarcoma treated at the West China Hospital, Sichuan University, Chengdu, Sichuan, China from 1985 to 2010. Clinicopathological parameters were analyzed to determine their impact on overall, recurrence-free and metastasis-free survivals. Results: A total of 46 women and 142 men were included, with a median age of 42 years. Of these, 152 cases were high-grade. The most common site was the paratesticular region. Surgical resection was carried out in 155 patients (82.4%), with negative margin in 106. After a minimum follow up of 5 years, 20 patients (11.6%) survived disease-free, 14 (8.1%) were alive with disease and 138 (80.2%) died of disease. Survival rates at 1, 3 and 5 years were 91.3%, 64.0% and 47.7%. In univariate analyses, liposarcoma, high grade, metastasis at diagnosis, a lack of surgical resection and positive margin were predictive of unfavorable survival. In multivariate analyses, high grade, a lack of surgical resection and chemotherapy were independent predictors of poor survival. Conclusions: Adult genitourinary sarcoma is an aggressive malignancy, usually presenting at advanced stage, with a high incidence of recurrence and metastasis. Complete resection and selective combination of chemotherapy and radiotherapy might constitute the optimal treatment for this disease.

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Section: Discussionmentioning

confidence: 99%

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Wang

Tan

et al. 2017

Int J of Urology

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“…Soft tissue sarcoma, specifically rhabdomyosarcoma, is the most common malignancy of the bladder in the pediatric population. (2)…”

Section: Introductionmentioning

confidence: 99%

Determinants of Survival for Adolescents and Young Adults with Urothelial Bladder Cancer: Results from the California Cancer Registry

Lara¹,

Brunson

Keegan

et al. 2016

Journal of Urology

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Purpose Bladder cancer is a common malignancy often diagnosed in older adults. Previous studies have reported racial/ethnic disparities in bladder cancer survival outcomes, but have not focused on younger patients. We sought to identify whether factors influencing cause-specific survival in adolescents and young adults (ages 15-39) differed from older adults, and to define prognostic factors specifically in adolescents and young adults using the California Cancer Registry. Materials and Methods Patients diagnosed with bladder cancer between 1988 through 2012 were included. The primary outcome measure was cause specific survival. A multivariable Cox proportional hazards regression model was used to evaluate predictors of cause-specific survival in patients of all ages and in adolescents/young adults. Interactions of age and other variables between younger and older adult patients were assessed. Results Of 104,974 bladder cancer patients, we identified 1,688 adolescent and young adult patients (1.6%). When compared to older patients, these patients had a 58% reduced risk of bladder cancer death (Hazard Ratio 0.42; p<0.001). Significant age interactions were identified involving race/ethnicity and histology. Among AYAs, non-Hispanic African Americans with low socioeconomic status had poor cause- specific (Hazard Ratio 7.1, p<0.001) and overall (Hazard Ratio 5.02, p<0.001) survival. Conclusions Racial/ethnic and socioeconomic disparities exist in adolescent and young adult patients with bladder cancer in California. Further studies are warranted to identify the underlying causes in order to overcome these disparities.

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“…In this aspect, there are a lot of scientific evidence in the treatment of rhabdomyosarcomas [9], where both chemotherapy, radiotherapy [9, 10], and radical cystectomy [11] are good options with similar results in this aggressive tumor.…”

Section: Discussionmentioning

confidence: 99%

Bladder Fetal Rhabdomyoma Intermediate Type

González-Pérez¹,

Álvarez‐Argüelles²,

Gutiérrez³

et al. 2017

Urol Int

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Introduction: Rhabdomyomas are benign tumors of striated muscle, the bladder localization is very rare. Clinical Case: We present an 87-year-old male consulting for gross hematuria. Cystoscopy was done with evidence of bulged bladder mucosa in right side wall and dome. Post-transurethral resection of the bladder (TURB) pathological anatomy was negative for malignancy. As extension study abdominopelvic computed tomography was performed identifying a bladder thickening of right posterior sidewall and an increased density of the adjacent fat. Second TURB was performed and a fetal bladder rhabdomyoma intermediate type was obtained. We performed another biopsy to confirm this rare pathology, with the same diagnosis. Subsequently, the patient continues with hematuria deciding on hemostatic radiotherapy (not candidate for cystectomy or arterial embolization). Currently, the patient is asymptomatic. Discussion: Bladder rhabdomyomas are rare tumors, and, in fact, there have been only 5 papers published. Some cases are only isolation cited in the bladder mesenchymal tumors, and other polemic cases in which clinical and macroscopic characteristics remembered a rhabdomyosarcoma. The importance of this publication case is the macro- and microscopic images that can corroborate the final diagnosis, helping us to differentiate between rhabdomyoma, rhabdomyofibroma, or the malignant rhabdomyosarcoma, and shows the treatment possibilities of these tumors.

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Oncologic Outcome and Urinary Function after Radical Cystectomy for Rhabdomyosarcoma in Children: Role of the Orthotopic Ileal Neobladder Based on 15-Year Experience at a Single Center

Cited by 16 publications

References 14 publications

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution

Determinants of Survival for Adolescents and Young Adults with Urothelial Bladder Cancer: Results from the California Cancer Registry

Bladder Fetal Rhabdomyoma Intermediate Type

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