Oncologic outcomes and technical considerations of nipple-sparing mastectomies in breast cancer: experience of 425 cases from a single institution

Abstract

NSM is safe with a low complication rate. No significant difference was observed in cumulative local recurrence rate, cumulative distant disease recurrence rate, and overall survival between patients who underwent NSM or conventional total mastectomy, confirming that NSM was surgically and oncologically safe.

Current status of breast reconstruction in China: an experience of 951 breast reconstructions from a single institute

“…However, the indication of NSM is still under debate. Multiple studies have demonstrated that tumor size, tumor location, LN metastasis, lymphovascular invasion, histologic type, immunological characteristics like HER2 should be taken into consideration when propose NSM to breast cancer patients (14)(15)(16). In terms of LRR of NSM, none of our cases developed loco-regional or distant recurrence because of relative short follow-up time and highly selective cases.…”

Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy

“…The mean follow-up time was 38 months (range, 7.4–156 months) and the overall LR rate was 2.38%. In recent years, studies have indicated that NSM was safe for oncology and led to similar LR and OS rates compared with those of patients treated with CM ( 18 , 34 ). These results were similar to those of the present study.…”

“…Numerous previous prospective and retrospective studies, comprising patients with varying sample sizes, inclusion criteria and follow-up durations, have reported an LR rate of 0–24% following NSM ( 12 , 16 – 18 , 32 – 34 ). Although Benediktsson and Perbeck ( 33 ) reported a highest LR rate of 24% among these studies, the NAC recurrence rate was 4%.…”

“…While a study undertaken by Adam et al ( 16 ) reported no LR in a group comprising 67 patients after 36 months. Shimo et al ( 34 ) determined an LR rate of 5.8% after 46.8 months (range, 6–158 months) for 425 patients who had undergone NSM and the cumulative LR rate at the NAC was 2.3%. Orzalesi et al ( 35 ) evaluated the oncological safety of NSM in a large sample size (1,006 cases), and reported an LR rate of 2.9% and a NAC recurrence rate of 0.7%.…”

A critical look at the effect of hyperbaric oxygen on the ischemic nipple following nipple sparing mastectomy and implant based reconstruction: a case series

“…Nipple sparing mastectomy (NSM) has been demonstrated to increase patient satisfaction and result in superior cosmetic outcomes compared to skin sparing mastectomy with nipple reconstruction (1,2). Over the past ten years, numerous studies have demonstrated NSM to be oncologically safe in appropriately selected patients and a viable alternative to skin-sparing mastectomy (3)(4)(5)(6). Based on the safety and efficacy of NSM and the possibility of aesthetic superiority, nipple preservation has become the preferred approach in the highest volume breast centers in the United States.…”