Oncologic outcomes of extended neck dissections in human papillomavirus‐related oropharyngeal squamous cell carcinoma

Zenga, Joseph; Pipkorn, Patrik; Graboyes, Evan M.; Martin, Eliot J.; Rich, Jason T.; Moore, Eric J.; Haughey, Bruce H.

doi:10.1002/hed.25060

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…4 Moreover, persistent HPV infections increase the risk cervical, vulvar, vaginal, penile, and throat cancers. [5][6][7][8] The primary modes of HPV transmission are sex and skin contact, 5 and HPV infection is the primary causative factor in >96% of cervical cancer cases. 9,10 Over 200 HPV genotypes have been identified, 11 but HPV is mainly divided into highrisk and low-risk genotypes according to their association with cancers.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus genotypes and infection among women in Changzhou, China

Geng

Liu

2019

Human Vaccines & Immunotherapeutics

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Human papillomavirus (HPV) infection is a major cause of cervical cancer. HPV vaccine has been shown to be highly effective in preventing HPV infection, and understanding the genotypes of HPV infection can guide the utilization of HPV vaccine. This epidemiological study aimed to investigate the genotype distribution of HPV in HPV-positive female patients in Changzhou. This study enrolled HPV-positive female patients admitted at the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University were enrolled in this study. HPV genotypes were identified via standard HPV DNA testing. The cohort comprised 5738 patients, that the predominant genotypes were HPV52 (13.4%), HPV16 (9.6%), HPV58 (8.8%), HPV81 (8.6%), and HPV53 (7.7%). HPV infection prevalence was the highest among those aged 41-45 y (16.6%), followed by those aged 31-35 y (15.1%) and 36-40 y (15.1%). In total, 46.8% of infections were found in women aged 31-45 y. The main genotypes of HPV infection upon physical examination or diagnosis of cervicitis and cervical cancer were HPV52,16, 58, 81, and 53. HPV52,16, 58, 81, and 53 are the most predominant genotypes of HPV infection. Further, HPV infection is most prevalent among women aged 31-45 y. Our findings provide experimental evidence for guiding HPV vaccination policy.

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Section: Introductionmentioning

confidence: 99%

Human papillomavirus genotypes and infection among women in Changzhou, China

Geng

Liu

2019

Human Vaccines & Immunotherapeutics

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“…6 Consent for publication Not applicable. 7 Competing interest authors declare that the research was conducted in the absence of any commercial or nancial relationships that could be construed as a potential con ict of interest.…”

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confidence: 99%

“…The surgical treatment of OSCC patients with ENE, who require removal of major muscular or neurovascular structures, has not been well investigated (4)(5)(6). In addition to treatment outcomes, postoperative complications should be considered in patients who underwent extended ND (7). The purpose of this study was to analyze the risk factors affecting the prognosis and regional recurrence of patients with OSCC requiring resection of non-lymphatic structures during ND due to ENE.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of extended neck dissection in oral squamous cell carcinoma: a retrospective study

Kugimoto

Oikawa

Kashima

et al. 2022

Preprint

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Background: Cervical lymph node metastasis with extranodal extension (ENE) is a poor prognostic factor for oral squamous cell carcinoma (OSCC). This study aimed to evaluate the treatment outcomes of OSCC patients who underwent extended neck dissection (ND), requiring resection of non-lymphatic structures for invasive nodal disease. Methods: Patients who underwent extended ND for OSCC at the Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University between April 2001 and December 2018 were retrospectively analyzed. Regional recurrence and complication were assessed. The primary outcome variable was 5-year disease-specific survival. Results: A total of 49 patients were included, and regional recurrence was found 18 patients (36.7%). There was no significant difference in the regional recurrence rate, regardless of whether the non-lymphatic structure requiring resection was single or multiple (29.6% vs 45.4%, P = 0.398). The regional recurrence rate was significantly higher in patients who required resection of neurovascular structures than in patients who did not require resection of these structures (64.3% vs 25.7%, P = 0.028). Cox proportional-hazards regression models indicated that types of resected non-lymphatic structures (with neurovascular structures) was the most risk factor for predicting the risk of regional recurrence (P = 0.048, hazard ratio = 2.59, 95% confidence interval: 1.01–6.66). Cox regression analysis to determine independent predictive factors for DSS, revealing that types of resected non-lymphatic structures (P=0.038, HR = 2.58, 95% CI: 1.05–6.33) was independent predictive factors for DSS. Patients who required resection of neurovascular structures had significantly worse the 5-year DSS rate than those who did not (23.4% vs 63.1%; P = 0.014). Complications after extended ND included recurrent nerve paralysis in three patients, facial nerve paralysis in two patients, and chyle leak, fracture of mandible, and urgent tracheostomy due to larynx edema in a patient, respectively. Conclusion: This study suggests that adhesion of metastatic lymph nodes to neurovascular structures is a significant poor prognostic factor for regional recurrence after extended ND. Patients with OSCC with adhesion of metastatic lymph nodes to neurovascular structures require an adequate safety resection margin and intensive postoperative treatment.

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Surgical Management of the Neck

Sakr

2022

Tongue Lesions

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Oncologic outcomes of extended neck dissections in human papillomavirus‐related oropharyngeal squamous cell carcinoma

Cited by 3 publications

References 25 publications

Human papillomavirus genotypes and infection among women in Changzhou, China

Human papillomavirus genotypes and infection among women in Changzhou, China

Prognostic impact of extended neck dissection in oral squamous cell carcinoma: a retrospective study

Surgical Management of the Neck

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