2019
DOI: 10.1016/s1569-9056(19)34611-1
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Oncological control in high-risk prostate cancer after radical prostatectomy and salvage radiotherapy compared to radiotherapy plus primary hormone therapy

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“…Interestingly, four studies used in both analyses indicated perfect comparability between RT and RP groups by Wallis et al, yet some of these studies did not control for study center [ 37 - 39 ], year of diagnosis [ 35 , 37 , 38 ], or demographic characteristics [ 38 ]. Since patients undergoing RT are more likely to be older, have poorer prognostic characteristics, and have sociodemographic characteristics that are associated with poorer CSM and ACM [ 11 , 20 , 29 ], we anticipate the influence of these unaccounted-for biases to overestimate CSM and ACM in the RT group relative to the RP group. However, the discrepancy in such baseline characteristics appears more prominent among those undergoing EBRT ± ADT rather than EBRT + BT ± ADT wherein patients are more similar to those undergoing RP [ 11 , 20 ].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, four studies used in both analyses indicated perfect comparability between RT and RP groups by Wallis et al, yet some of these studies did not control for study center [ 37 - 39 ], year of diagnosis [ 35 , 37 , 38 ], or demographic characteristics [ 38 ]. Since patients undergoing RT are more likely to be older, have poorer prognostic characteristics, and have sociodemographic characteristics that are associated with poorer CSM and ACM [ 11 , 20 , 29 ], we anticipate the influence of these unaccounted-for biases to overestimate CSM and ACM in the RT group relative to the RP group. However, the discrepancy in such baseline characteristics appears more prominent among those undergoing EBRT ± ADT rather than EBRT + BT ± ADT wherein patients are more similar to those undergoing RP [ 11 , 20 ].…”
Section: Discussionmentioning
confidence: 99%