Oncological Outcomes of Lobar Resection, Segmentectomy, and Wedge Resection for T1a Non–Small-Cell Lung Carcinoma: A Systematic Review and Meta-Analysis

Ijsseldijk, Michiel A.; Shoni, Melina; Siegert, Charles; Seegers, J.; Engelenburg, Anton K.C. van; Tsai, Thomas C.; Lebenthal, Abraham; Broek, Richard P. G. ten

doi:10.1053/j.semtcvs.2019.08.004

Cited by 38 publications

(34 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thoracoscopic segmentectomy is increasingly becoming a popular procedure in thoracic surgery, and is utilized as a more prominent option for the treatment of small‐sized early‐stage lung cancers 16 . Recently, many studies have demonstrated that VATS segmentectomy for early‐stage lung cancers provides equivalent oncologic outcomes and greater preservation of lung function compared with lobectomy 2, 17, 18 .…”

Section: Discussionmentioning

confidence: 99%

Combination of nitrous oxide and the modified inflation‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

Background During thoracoscopic segmentectomy, accurately and rapidly identifying the intersegmental plane (ISP) is of great importance. This study aimed to investigate the effect and safety of a nitrous oxide (N2O)/oxygen (O2) inspired mixture on the appearance time of the ISP (TISP) via the modified inflation‐deflation method. Methods A total of 65 participants who underwent segmentectomy were randomized into three groups: 75% N2O (n = 24), 50% N2O (n = 23) or 0% N2O (n = 18). The 75% N2O group received a gas mixture of N2O/O2 (Fio2 = 0.25), the 50% N2O group received N2O/O2 (Fio2 = 0.5), and the 0% N2O group received 100% oxygen during lung expansion. The appearance time of satisfactory and ideal planes was recorded. Furthermore, arterial blood gas at breathing room air, one‐lung ventilation (OLV) before lung expansion, 5 and 15 min after lung expansion were also recorded. Results TISP was significantly shorter in the 75% N2O group (320.2 ± 65.9 s) compared with that of the 50% N2O group (552.4 ± 88.9 s, p < 0.001) and the 0% N2O group (968.3 ± 85.5 s, p < 0.001), while the 50% N2O group was shorter than that of the 0% N2O group (p < 0.001). Arterial oxygenation was significantly improved in the 0% N2O group only after lung expansion, before which there were no differences in mean PaO2 values among groups. Conclusions The use of N2O in the inspired gas mixture during lung expansion is an applicable strategy to rapidly identify the ISP via the modified inflation‐deflation method without any adverse effect on OLV related arterial oxygenation during segmentectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Combination of nitrous oxide and the modified inflation‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Sublobar resection was previously considered as a palliative surgery for high-risk patients with NSCLC. Several recent studies have demonstrated comparable recurrence and survival rates between sublobar resection and lobectomy for early-stage NSCLC, and the optimal strategy for early-stage NSCLC remains a subject of debate (9,10). Lobectomy remains the standard choice for NSCLC, and has been shown to minimize the risk of recurrence and optimize the chances for long-term survival.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have reported an association between preoperative RDW levels and the long-term prognosis of patients with non-small cell lung cancer (NSCLC) to date. Historically, the standard surgical strategy for NSCLC has been lobectomy, although previous studies have also included cases of sublobar resection, the curability of which remains debatable (9,10).…”

Section: Introductionmentioning

confidence: 99%

Prognostic effect of preoperative red cell distribution width on the survival of patients who have undergone surgery for non‑small cell lung cancer

et al. 2021

View full text Add to dashboard Cite

Red cell distribution width (RDW) is a prognostic factor for various malignancies, including colorectal, breast and lung cancer. The effect of preoperative RDW on the prognosis of patients who have undergone surgery for non-small cell lung cancer (NSCLC) was investigated in the present study. This retrospective, single-institution study included consecutive patients who had undergone complete NSCLC resection

show abstract

“…With the popularization of low-dose computed tomography (LDCT) for lung cancer screening, the detection rate for patients with early lung cancer has improved [7], and segmentectomy is more widely used as a surgical treatment. Recent studies have shown that NSCLC patients that received segmentectomies for lesions < 2 cm had similar oncologic effects compared with those that received lobectomies [8,9,10,11]. Patients receiving segmentectomies also had more protected lung function [12,13].…”

Section: Discussionmentioning

confidence: 99%

Lobectomy Versus Segmentectomy in Patients with Stage T (>2 cm and ≤3 cm) N0M0 Non-small Cell Lung Cancer: A Propensity Score Matching Study

Wang¹,

Ren³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Whether lung segmentectomy is a safe and effective surgical treatment in patients with early non-small cell lung cancer (NSCLC) remains controversial. We have therefore reviewed the clinicopathologic characteristics and survival outcomes of patients receiving a lobectomy vs. segmentectomy to treat early T (>2 cm and ≤3 cm) N0M0 NSCLC.Methods: We obtained data from the Surveillance, Epidemiology, and End Results (SEER) database for patients who underwent lobectomy or segmentectomy between 2004 and 2015. To reduce bias and imbalance between the treatment groups, propensity score matching (PSM) analysis was performed. We used Kaplan-Meier curves to estimate overall survival (OS) and lung cancer-speciﬁc survival (LCSS), performed univariate and multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for OS and CSS, and applied the Cox proportional hazards model to create forest plots. Results: A total of 5783 patients from the SEER database were included. Of these, 5531 patients underwent lobectomy, and 252 patients underwent segmentectomy. Before matching, both univariate and multivariate Cox regression analyses showed that patients who underwent lobectomy had better OS (hazard ratio [HR]: 1.561; 95% confidence interval [CI] 1.292-1.885; P <0.001) and LCSS (HR: 1.551; 95% CI 1.198-2.009; P=0.001) than patients who underwent segmentectomy. However, survival differences between the groups were not significant; OS (P=0.160) and LCSS (P=0.097) after matching. Regression analyses revealed that age, sex, lymph node dissection, and grade were independent predictors of OS and LCSS (P <0.05).Conclusions: For patients with stage T (>2 cm and ≤3 cm) N0M0 non-small cell lung cancer, segmentectomy can achieve the same OS and LCSS compared with lobectomy. A large number of patients require further long-term follow-up analyses.

show abstract

Oncological Outcomes of Lobar Resection, Segmentectomy, and Wedge Resection for T1a Non–Small-Cell Lung Carcinoma: A Systematic Review and Meta-Analysis

Cited by 38 publications

References 17 publications

Combination of nitrous oxide and the modified inflation‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial

Combination of nitrous oxide and the modified inflation‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial

Prognostic effect of preoperative red cell distribution width on the survival of patients who have undergone surgery for non‑small cell lung cancer

Lobectomy Versus Segmentectomy in Patients with Stage T (>2 cm and ≤3 cm) N0M0 Non-small Cell Lung Cancer: A Propensity Score Matching Study

Contact Info

Product

Resources

About

Oncological Outcomes of Lobar Resection, Segmentectomy, and Wedge Resection for T1a Non–Small-Cell Lung Carcinoma: A Systematic Review and Meta-Analysis

Cited by 38 publications

References 17 publications

Combination of nitrous oxide and the modified inflation‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial

Combination of nitrous oxide and the modified inflation‐deflation method for identifying the intersegmental plane in segmentectomy: A randomized controlled trial

Prognostic effect of preoperative red cell distribution width on the survival of patients who have undergone surgery for non‑small cell lung cancer

Lobectomy Versus Segmentectomy in Patients with Stage T (&gt;2 cm and ≤3 cm) N0M0 Non-small Cell Lung Cancer: A Propensity Score Matching Study

Contact Info

Product

Resources

About

Lobectomy Versus Segmentectomy in Patients with Stage T (>2 cm and ≤3 cm) N0M0 Non-small Cell Lung Cancer: A Propensity Score Matching Study