Oncological results of oncoplastic breast-conserving surgery: Long term follow-up of a large series at a single institution

Lorenzi, Francesca De; Hubner, Gabriel; Rotmensz, Nicole; Bagnardi, Vincenzo; Loschi, Pietro; Maisonneuve, Patrick; Venturino, Marco; Orecchia, Roberto; Galimberti, Viviana; Veronesi, Giulia; Rietjens, Mario

doi:10.1016/j.ejso.2015.08.160

Cited by 113 publications

(84 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, by including both breast conservative and radical surgeries, our study reflects the current clinical practices on management of breast cancer stage I and II with the evolution of techniques and therapeutics. 29 Our findings therefore highlight that MAT inflammation associated with excess weight might have important implications in clinical practice since it concerns a large majority of patients treated for breast cancer.…”

Section: Discussionmentioning

confidence: 74%

Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer

et al. 2017

View full text Add to dashboard Cite

Growing evidence indicates that adiposity is associated with breast cancer risk and negatively affects breast cancer recurrence and survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other adipose depots, occurrence of a sub-inflammatory state of mammary adipose tissue defined by dying adipocytes surrounded by macrophages forming crown-like structures in overweight and obese subjects, remains only partially described. In a general population of breast cancer patients (107 patients) mostly undergoing breast-conserving surgery, we found a positive association between patient’s body composition, breast adipocytes size, and presence of crown-like structures in mammary adipose tissue close to the tumor. Overweight (BMI: 25.0–29.9 kg/m2) and obese (BMI ≥ 30.0 kg/m2) patients have 3.2 and 6.9 times higher odds ratio of crown-like structures respectively, compared with normal weight patients. The relatively small increase in adipocyte size in crown-like structures positive vs. negative patients suggests that mammary adipose tissue inflammation might occur early during hypertrophy. Our results further highlight that body mass index is an adequate predictor of the presence of crown-like structures in mammary adipose tissue among postmenopausal women, whereas in premenopausal women truncal fat percentage might be more predictive, suggesting that mammary adipose tissue inflammation is more likely to occur in patients exhibiting visceral obesity. Finally, the presence of crown-like structures was positively associated with systemic markers such as the Triglyceride/High-density lipoprotein-cholesterol ratio serum C-reactive protein and glucose/(HbA1c) glycated Haemoglobin. These compelling results demonstrate that excess adiposity, even in overweight patients, is associated with mammary adipose tissue inflammation, an event that could contribute to breast cancer development and progression.

show abstract

Section: Discussionmentioning

confidence: 74%

Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…TM procedures are more complex than standard BCS, with potential resource implications. Although complication rates and oncological safety have been reported in the literature the majority of published studies are retrospective, single‐centre, often single‐surgeon case series with limited follow‐up. Many are poorly designed and reported, with inconsistent end‐points that limit cross‐study comparison and meaningful data synthesis.…”

Section: Introductionmentioning

confidence: 99%

Current practice and short-term outcomes of therapeutic mammaplasty in the international TeaM multicentre prospective cohort study

O’Connell

Baker

Trickey

et al. 2018

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…In the recent decades, the surgical management of breast cancer has steadily evolved from radical surgery to breast conservation. As a result, oncoplastic surgical techniques have emerged and are expanding dramatically . Oncoplastic surgery combines oncologic resection with immediate breast reconstruction using techniques derived from plastic surgery.…”

Section: Discussionmentioning

confidence: 99%

Oncoplastic breast surgery: Achieving oncological and aesthetic outcomes

Paridon

Kamali

Paul

et al. 2017

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Oncological results of oncoplastic breast-conserving surgery: Long term follow-up of a large series at a single institution

Cited by 113 publications

References 41 publications

Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer

Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer

Current practice and short-term outcomes of therapeutic mammaplasty in the international TeaM multicentre prospective cohort study

Oncoplastic breast surgery: Achieving oncological and aesthetic outcomes

Contact Info

Product

Resources

About