Oncological safety of reconstruction with autologous fat grafting in breast cancer patients: a systematic review and meta-analysis

Sun, Jiale; Li, He; Lin, Dongcai; Han, Bing; Zhang, Tiran; Gao, Jidong

doi:10.1007/s10147-022-02207-8

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…Similarly, Kronowitz et al 30 also reported similar locoregional or systemic cancer risk in women who did and did not receive postmastectomy lipid transfer. This evidence is reinforced by systematic reviews documenting no significantly increased disease recurrence in patients who received AFG 9,31 . Collectively, clinical studies demonstrate a high safety profile for fat grafting as a means of improving aesthetic outcomes after breast reconstruction.…”

Section: Discussionmentioning

confidence: 92%

Proliferation Patterns of MCF-7 Breast Cancer Cells in Lipoaspirate Conditioned Media

Chen,

Arbuiso,

Qin

et al. 2024

Ann Plast Surg

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Introduction Autologous fat grafting (AFG) is a common technique used to enhance aesthetic outcomes in postmastectomy breast reconstruction patients. Adipokines are hormones secreted by adipose tissue that play a critical role in regulating metabolic processes and the immune system. However, dysregulated adipokine secretion and signaling can contribute to the development and progression of cancer by promoting angiogenesis, altering the immune response, and inducing the epithelial mesenchymal transition. We aimed to assess how breast cancer cells behave in conditioned media derived from fat grafting lipoaspirates and gain a better understanding of the potential interactions that may occur within the tumor microenvironment. Methods Patients who were undergoing AFG as a part of breast reconstruction at NY-Presbyterian/Weill Cornell Medical Center between March 2021 and July 2023 were consented and enrolled in the study. This study was approved by the Weill Cornell Medicine Institutional Review Board (#20-10022850-14). Conditioned media is created using 20% of patient lipoaspirate secretome and 80% starving media. The growth of MCF-7, a human ER/PR+ breast cancer cell line, in conditioned media is assessed using CyQUANT. Results The breast cancer cells incubated in conditioned media displayed similar growth trends as those in complete media, which is enriched for cell growth (P > 0.05). MCF-7 cell behavior in conditioned media differed significantly from their proliferation patterns when serum starved in 100% starving media (P < 0.05). Discussion Our results suggest that there may be inherent factors within the lipoaspirate that may promote MCF-7 proliferation. One potential implication is that AFG used for breast reconstruction should be delayed until local-regional disease control has been established. In addition, based on the in vitro proliferation patterns of breast cancer cells in conditioned media, the safety profile of AFG may be enhanced if the procedure is performed after attaining negative margins and the completion breast cancer treatment.

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Section: Discussionmentioning

confidence: 92%

Proliferation Patterns of MCF-7 Breast Cancer Cells in Lipoaspirate Conditioned Media

Chen,

Arbuiso,

Qin

et al. 2024

Ann Plast Surg

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“…The idea that the adipose stem cells contained in the fat graft may stimulate the proliferation of cancer cells makes many surgeons hesitant in the application of fat grafts. However, studies indicate that fat graft applications do not increase recurrence and metastasis [106].…”

Section: Reconstruction: When and How?mentioning

confidence: 99%

Solutions in Breast Reconstruction

Karakol¹,

Noyan²,

Ömer³

2023

Breast Cancer Updates

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Breast reconstruction, after cancer surgery, is not only a reconstructive surgery but also an esthetic surgery. No woman should be expected to give up the breast tissue, which is the symbol of female identity, easily. The reconstruction stage after breast cancer is difficult enough in the early and late stages. It is generally not possible to cover the defect and to equalize the two breasts in a single step. General surgery and plastic surgery should work together. Recently, innovative solutions have been offered in breast reconstruction. Starting from skin grafts and local flaps, various flap options, dermal equivalents, fat transfer, and tissue expansion operations are among the options. Breast reconstruction is difficult enough in breasts that have undergone radiotherapy, and reconstruction with autologous tissue is preferred.

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Dissecting the emerging role of cancer-associated adipocyte-derived cytokines in remodeling breast cancer progression

Yang,

Zeng,

et al. 2024

Heliyon

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Oncological safety of reconstruction with autologous fat grafting in breast cancer patients: a systematic review and meta-analysis

Cited by 4 publications

References 55 publications

Proliferation Patterns of MCF-7 Breast Cancer Cells in Lipoaspirate Conditioned Media

Proliferation Patterns of MCF-7 Breast Cancer Cells in Lipoaspirate Conditioned Media

Solutions in Breast Reconstruction

Dissecting the emerging role of cancer-associated adipocyte-derived cytokines in remodeling breast cancer progression

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