Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

Abstract

In this study of patients with retroperitoneal, complete resection and liposarcoma histology are prognostic factors related to the disease-free and overall survival. Patients approached with curative intent should undergo aggressive attempts at complete surgical resection.

Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan

“…Benign tumors comprised 42.2% of all studied retroperitoneal tumors, and were more common than intermediate or malignant tumors. Schwannoma is usually diagnosed in patients aged 21–40 years, and it was the most common benign tumor in our cohort . Benign tumors were more frequently found in the younger population, and 64.7% of our patients aged younger than 30 years had benign tumors.…”

Comprehensive Surgical Treatment as the Mainstay of Management in Retroperitoneal Sarcomas: Retrospective Study from Two Non-sarcoma Specialist Centers

“…These constrains limit the surgeon's ability to perform wide resection with clear margins. Importantly, incomplete surgical resection comprises one of the greatest risk factors for early relapse and poor survival in patients with RPS (4,16,17,19,(21)(22)(23)(24). It is, therefore, not surprising that management guidelines recommend that surgical resections should be undertaken at specialist sarcoma centers by surgeons with experience and expertise in such complex procedures (4,22,25,26).…”

“…This approach was well tolerated by the majority of patients, independent of their age and performance status. A combination of surgical techniques including complex and demanding techniques, such as full liver mobilization, subdiaphragmatic Inferior vena cava control, iliac dissection, vascular interpositions and organ revascularization were used when needed (23,27,28).…”

“…At 5 and 10 years, disease-free survival was 80% and 80% in those with low-grade and 53% and 43% in those with high-grade tumors, respectively, *p=0.018. in locoregional recurrence) (13,17,18,23,29), we first performed this technique for a small subgroup of young patients with good performance status (13,14). Since 2012 when an international consensus on the performance of surgery in RPS was reached, presented and standardized, this method has been increasingly used by our teams (data not included in this study) (30).…”

“…Since 2012 when an international consensus on the performance of surgery in RPS was reached, presented and standardized, this method has been increasingly used by our teams (data not included in this study) (30). The patients are of course informed about the potential morbidity of this procedure and the fact that there is a trend for survival benefit over contiguously involved organ resection (23). Simple resection is used with palliative rather than curative intent in the case of elderly patients with comorbidities, poor performance status and giant retroperitoneal tumors, who, a priori, are thought to have worse prognosis (4,10).…”