2012
DOI: 10.1038/nbt.2287
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Oncolytic virotherapy

Abstract: Oncolytic virotherapy is an emerging treatment modality which uses replication competent viruses to destroy cancers. Advances in the past two years include preclinical proof of feasibility for a single-shot virotherapy cure, identification of drugs that accelerate intratumoral virus propagation, new strategies to maximize the immunotherapeutic potential of oncolytic virotherapy, and clinical confirmation of a critical viremic thereshold for vascular delivery and intratumoral virus replication. The primary clin… Show more

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Cited by 1,241 publications
(1,400 citation statements)
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References 160 publications
(195 reference statements)
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“…8 Moreover, proinflammatory cytokines generated in the virus-infected cancer cells can restore the immunosuppressive tumor microenvironment. [9][10][11] Thus, oncolytic viruses are recently viewed as anticancer immunotherapeutic agents. These backgrounds make it imperative to update the molecular pathways and/or cellular constituents that regulate ICD.…”
Section: Open Questionsmentioning
confidence: 99%
“…8 Moreover, proinflammatory cytokines generated in the virus-infected cancer cells can restore the immunosuppressive tumor microenvironment. [9][10][11] Thus, oncolytic viruses are recently viewed as anticancer immunotherapeutic agents. These backgrounds make it imperative to update the molecular pathways and/or cellular constituents that regulate ICD.…”
Section: Open Questionsmentioning
confidence: 99%
“…Orthotopic cancer models in immunocompetent animals susceptible to the oncolytic virus represent the most reliable and predictive preclinical model for oncolytic virotherapy. 29 An immune response could, in fact, limit viral spread, hence, causing a decrease of cytotoxic effects as it has been shown for adenoviral vectors. 30,31 Besides, a very strong immune response could hypothetically trigger a fatal inflammation leading to death.…”
Section: Discussionmentioning
confidence: 98%
“…Oncolytic viruses have promising application in cancer therapy,13 while the clinical applications are restricted by virus‐associated safety issues. [[qv: 5a,14]] Previously, many attempts have been performed to reduce the virus‐associated safety issues by virus modification 15.…”
Section: Discussionmentioning
confidence: 99%