Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer

Zhao, Guomeng; Zhang, Hongying; Zhang, Yanchao; Zhao, Na; Mao, Jinlei; Shang, Pengzhao; Gao, Kun; Ye, Meng; Tao, Yuhang; Wang, Anlei; Chen, Ziyi; Guo, Cui

doi:10.1007/s10565-022-09784-4

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…FA serves as an epidermal growth factor (EGF) at low concentrations, activating the HER2 receptor and downstream signaling pathways in HER2 + breast cancer cells, resulting in increased cell proliferation. The PI3K/PKC/CK2 axis regulates SET nucleocytoplasmic tra cking, and SET depletion or blockage reduces EGF-induced activation of AKT and ERK (G Zhao et al, 2022)…”

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confidence: 99%

LINC1521 and miR-3679-5p modulate cellular response to chemical stress in breast cancer patients through regulation of XBP1 expression as a potential diagnostic biomarker

Shirdeli,

Hashemi,

hashemi

et al. 2023

Preprint

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Background The majority of breast cancer (BC) patients die of metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly understood. Long noncoding RNAs (lncRNA) have been shown to regulate cancer occurrence and progression. However, the lncRNAs that drive metastasis in cancer patients and their underlying mechanisms are still largely unknown. In this study, expression, interaction, and related pathways of XBP1 and a novel regulatory non-coding RNA, LINC01521 is evaluated in BC patients. Methods Microarray data analysis was performed using R Studio (4.1.2). GSE71052 was used in this study. miRNA interaction analysis carried out using miRWalk. lncRNA-mRNA interaction analysis was conducted using lncRRIsearch. Expression and survival analysis was performed by GEPIA2. Illustration of interaction analyses was performed by cytoscape. The qRT-PCR experiment was performed for the validation of expression results. Results XBP1 (logFC:, p-value: ) and LINC01521 (logFC:, p-value: ) have significant up-regulation in BC and could be the two potential diagnostic biomarker of BC. Up-regulation of XBP1 observed in bioinformatics analyses and supported by experimental results in this study. XBP1 regulates the function of HMOX1 in cellular response to chemical stress signaling pathway. miR-3679-5p suppresses the expression level of XBP1 (energy: -30.5, score: 1, position: 3’UTR). XBP1 also involved in Response To Interleukin-4 (GO:0070670) and Positive Regulation Of B Cell Differentiation (GO:0045579) biological processes. Conclusion miR-3679-5p as a novel miRNA and LINC01521 as a potential oncogene and diagnostic biomarker might modulate cellular response to chemical stress signaling pathway in BC patients through regulation of XBP1, a BC oncogene.

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confidence: 99%

LINC1521 and miR-3679-5p modulate cellular response to chemical stress in breast cancer patients through regulation of XBP1 expression as a potential diagnostic biomarker

Shirdeli,

Hashemi,

hashemi

et al. 2023

Preprint

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Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner

et al. 2023

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Background Metformin, a rst-line oral anti-diabetic drug, has recently been reported to exert protective effect on various cardiovascular diseases. However, the potential role of metformin in ethanol-induced cardiomyocyte injury is still unknown. Therefore, this study was aimed to investigate the effect of metformin on ethanol-induced cardiomyocyte injury and its underlying mechanism.Methods and Results H9c2 cardiomyocytes were exposed to ethanol for 24 h to establish an ethanolinduced cardiomyocyte injury model, and followed by treatment with metformin in the presence or absence of Lapatinib (an ErbB2 inhibition). CCK8 and LDH assays demonstrated that metformin suppressed cardiomyocyte apoptosis induced by ethanol exposure. Furthermore, the up-regulated expressions of apoptosis-related proteins (Bax and C-CAS-3) were also reduced by metformin. In addition, our results showed that metformin activated the AKT/Nrf2 pathway, and then promoted Nrf2 nuclear translocation and the transcription of its downstream antioxidant genes (HO-1, CAT and SOD2), thereby inhibiting oxidative stress. Interestingly, we found that ErbB2 expression was signi cantly inhibited in ethanol-treated cardiomyocyte, which was markedly reversed by metformin. In contrast, Lapatinib largely abrogated the activation of AKT/Nrf2 signaling by metformin, accompanied by the increases in oxidative stress and cardiomyocyte apoptosis,indicating that metformin prevented ethanol-induced cardiomyocyte injury in an ErbB2-dependent manner.Conclusions In summary, our study provides the rst evidence that metformin protects cardiomyocyte against ethanol-induced oxidative stress and apoptosis by activating ErbB2-mediated AKT/Nrf2 signaling. Thus, metformin may be a potential novel treatment approach for alcoholic cardiomyopathy.

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Application of stress granule core element G3BP1 in various diseases: A review

Guo,

Huang,

Mei

et al. 2024

International Journal of Biological Macromolecules

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Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer

Cited by 3 publications

References 47 publications

LINC1521 and miR-3679-5p modulate cellular response to chemical stress in breast cancer patients through regulation of XBP1 expression as a potential diagnostic biomarker

LINC1521 and miR-3679-5p modulate cellular response to chemical stress in breast cancer patients through regulation of XBP1 expression as a potential diagnostic biomarker

Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner

Application of stress granule core element G3BP1 in various diseases: A review

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