Oncothermia as Personalized Treatment Option

Szász, Olivér; Andócs, Gábor; Meggyesházi, Nóra

doi:10.1155/2013/941364

Cited by 7 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oncothermia is a capacitive impedance coupled energyabsorption, it heats the sensitive parts of the malignant cells selectively and effectively. The details of these effects were discussed in numerous papers and chapters of books [43,[46][47][48][49][50][51][52][53].…”

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

“…The Radiofrequency (RF) current is chosen with a proper amplitude modulated radiofrequency [71], which is absorbed by the nanoscopic range of the malignant cells (45). The physiological differences of the malignant cells from their healthy counterparts [68] distinguishes the malignancy which is self-selected by additional time-fractal modulation [72], and on such way it is also highly personalized [73].…”

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

“…• Heat increases the influx of reactive oxygen radicals mediating in part the cytotoxicity • Hyperthermia in combination with drugs promoting apoptosis, has synergistic effect [76] The greater sensitivity of tumor cells to heat depends from these biochemical effects but also by the microenvironment in which the tumor cells are embedded [73,74].…”

Section: • Mitochondria Suffer Different Alterations In Their Cristaementioning

confidence: 99%

See 2 more Smart Citations

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

View full text Add to dashboard Cite

Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the conventional methods of treatment: surgery, radiotherapy, chemotherapy and immunotherapy. Recent trials in Holland and Germany have demonstrated that hyperthermia can prolong life and decrease disease re-appraisal when used in combination with radiotherapy and chemotherapy. Some tumors seem more responsive than others. In this brief summary we will attempt to give a vision of hyperthermia from a physical stand point, but more importantly we will give clinical and biological aspects. The results obtained in these trials on certain types of cancers such as cervix cancer, recurrent breast cancer and head neck cancer, melanoma, sarcomas, liver, glioblastoma and pancreatic cancer support the use of this technique, although some clinical and technical problems persist and have not been completely resolved.

show abstract

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

Section: • Mitochondria Suffer Different Alterations In Their Cristaementioning

confidence: 99%

See 1 more Smart Citation

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

View full text Add to dashboard Cite

show abstract

“…The non-homogeneous induced heating in mEHT allows the application of a high precision hyperthermia (415), which is personalized (416). The well-focused energy absorption reduces the heating of non-malignant parts in the target, reducing the energy loss and increasing the efficacy of the treatment.…”

Section: Proposal For the Change Of Paradigmmentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

View full text Add to dashboard Cite

Heating as a medical intervention in cancer treatment is an ancient approach, but effective deep heating techniques are lacking in modern practice. The use of electromagnetic interactions has enabled the development of more reliable localregional hyperthermia (LRHT) techniques whole-body hyperthermia (WBH) techniques. Contrary to the relatively simple physical-physiological concepts behind hyperthermia, its development was not steady, and it has gone through periods of failures and renewals with mixed views on the benefits of heating seen in the medical community over the decades. In this review we study in detail the various techniques currently available and describe challenges and trends of oncological hyperthermia from a new perspective. Our aim is to describe what we believe to be a new and effective approach to oncologic hyperthermia, and a change in the paradigm of dosing. Physiological limits restrict the application of WBH which has moved toward the mild temperature range, targeting immune support. LRHT does not have a temperature limit in the tumor (which can be burned out in extreme conditions) but a trend has started toward milder temperatures with immune-oriented goals, developing toward immune modulation, and especially toward tumor-specific immune reactions by which LRHT seeks to target the malignancy systemically. The emerging research of bystander and abscopal effects, in both laboratory investigations and clinical applications, has been intensified. Our present review summarizes the methods and results, and discusses the trends of hyperthermia in oncology.

show abstract

“…The efficacy of energy delivery also must be optimal, which has been shown for mEHT (125). The mEHT method is highly personalized (55,141) and thus minimizes adverse effects. Consequently, the dose of mEHT could be the same as for ionizing radiation, with the energy defined as J/kg (Gy) or Ws/kg.…”

Section: Concept: Dose Model Of Modulated Electro-hyperthermiamentioning

confidence: 99%

Oncological hyperthermia: The correct dosing in clinical applications

2018

View full text Add to dashboard Cite

The problem with the application of conventional hyperthermia in oncology is firmly connected to the dose definition, which conventionally uses the concept of the homogeneous (isothermal) temperature of the target. Its imprecise control and complex evaluation is the primary barrier to the extensive clinical applications. The aim of this study was to show the basis of the problems of the misleading dose concept. A clear clarification of the proper dose concept must begin with the description of the limitations of the present doses in conventional hyperthermia applications. The surmounting of the limits the dose of oncologic hyperthermia has to be based on the applicability of the Eyring transition state theory on thermal effects. In order to avoid the countereffects of thermal homeostasis, the use of precise heating on the nanoscale with highly efficient energy delivery is recommended. The nano-scale heating allows for an energy-based dose to control the process. The main aspects of the method are the following: i) It is not isothermal (no homogeneous heating); ii) malignant cells are heated selectively; and iii) it employs high heating efficacy, with less energy loss. The applied rigorous thermodynamical considerations show the proper terminology and dose concept of hyperthermia, which is based on the energy-absorption (such as in the case of ionizing radiation) instead of the temperature-based ideas. On the whole, according to the present study, the appropriate dose in oncological hyperthermia must use an energy-based concept, as it is well-known in all the ionizing radiation therapies. We propose the use of Gy (J/kg) in cases of non-ionizing radiation (hyperthermia) as well.

show abstract

Oncothermia as Personalized Treatment Option

Cited by 7 publications

References 25 publications

A Brief Overview of Hyperthermia in Cancer Treatment

A Brief Overview of Hyperthermia in Cancer Treatment

Quo Vadis Oncological Hyperthermia (2020)?

Oncological hyperthermia: The correct dosing in clinical applications

Contact Info

Product

Resources

About