Ondansetron is a better prophylactic antiemetic than droperidol for tonsillectomy in children

Abstract

Both intravenous ondansetron (OND) and droperidol (DROP)have

Combination of droperidol and ondansetron reduces PONV after pediatric strabismus surgery more than single drug therapy

“…Ondansetron, a 5HT 3 antagonist, has been found to be an effective antiemetic in various surgical populations (18, 19). Ondansetron when compared with placebo and other antiemetics in pediatric patients undergoing strabismus surgery has been shown to be as effective or better than droperidol or metoclopramide and more effective than placebo (8, 10, 20).…”

Current Management of Vomiting After Tonsillectomy in Children

“…These tablets were also effective for the prevention of at-home emesis during the first 3 days after tonsillectomy [35]. In comparative studies, Furst et al [5], Stene et al [9], Splinter et al [36], and Bolton et al [48] demonstrated that ondansetron 0.1-0.15 mg kg -1 , administered IV after inhalation induction of anesthesia, was more effective than metoclopramide 0.25-0.5 mg kg -1 or droperidol 50-75 mcg kg -1 for the prevention of POV. Similarly, Hamid et al compared the effectiveness of ondansetron 0.1 mg kg -1 , dimenhydrinate 0.5 mg kg -1 , and placebo for the prevention of POV, and concluded that ondansetron was superior to dimenhydrinate or placebo [15].…”

When placebo controlled trials are essential and equivalence trials are inadequate

“…Ten patients (0.2% of all patients) were admitted or readmitted to hospital because of excessive or prolonged postoperative nausea and vomiting (five children had received droperidol 50 µg/kg or 75 µg/kg, 20 22 42 two children ondansetron 150 µg/kg,42 and one adult metoclopramide 10 mg,28 and in two adults the treatment was not specified33). …”