Ondansetron-loaded chitosan microspheres for nasal antiemetic drug delivery: an alternative approach to oral and parenteral routes

Güngör, Sevgi; Okyar, Alper; Erturk-Toker, Sidika; Baktir, G.; Özsoy, Yıldız

doi:10.3109/03639040903517906

Cited by 32 publications

(15 citation statements)

References 29 publications

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“…Besides, the loss of the material during the spray-drying process was explained with the polymer film adhesion on the cyclon walls. The low yield values for spraydrying process were also because of the loss of lightest particles through the exhaust of the spray-dryer apparatus as it is not equipped with a trap to recover the lighter and smaller particles as reported by other researchers 34 . 2.…”

Section: Drug Release Studymentioning

confidence: 91%

“…Percentage yield 22 : The Production yield was calculated as the weight of the final product after drying, with respect to the initial total amount of Levosalbutamol sulphate and polymer used for the preparation of microspheres. 22,23 :…”

Section: Methodsmentioning

confidence: 99%

“…Particle size distribution 26 : Particle size distribution of batches was carried out by Malverrn Master sizer. The microspheres were dispersed in Isopropyl alcohol.…”

Section: Drug Loading and Entrapment Efficiencymentioning

confidence: 99%

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2013

IJPSR

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ABSTRACT:Objective: To formulate and evaluate the Levosalbutamol sulphate loaded microspheres of Chitosan and microspheres of Flax seed Mucilage in which both the polymers were checked as potential mucoadhesive agents and crosslinking was done with Glutaraldehyde for prolonging drug release for asthma therapy. Material and Method: Chitosan and Flax seed mucilage (by drying in Hot Air Oven) were used in appropriate concentration and crosslinked microspheres were prepared by Spray drying. They were evaluated for %Entrapment efficiency, Swelling behavior, %Mucoadhesion and Invitro drug release. The optimized batches were subjected to Particle-size distribution, Scanning-electron microscopy, Aerosolization behavior and Stability study. Result and Discussion: Microspheres having Chitosan polymer: Drug ratio of 2:1 and 0.6% of Glutaraldehyde and that of Flax seed Mucilage: Drug ratio of 3:1 and 0.9% of Glutaraldehyde had good mucoadhesion ability (89.50% and 85.11% respectively). Release rate was retarded up to 8 h and follows non-fickian diffusion. Particle-size distribution of optimized batches was represented by span index (3.822 and 2.953 respectively) and value was nearer to marketed product (1.975). Aerosolization behavior could be comparable with marketed product.

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Section: Drug Release Studymentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

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2013

IJPSR

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“…As reported by earlier findings an optimum diameter for nasal microspheres has to be >5-10 µm. [28][29][30][31][32] Particles <5 µm escape to the lungs, whereas larger particles may deposit on the nasal mucus membrane, with larger ones depositing more anteriorly. [33,34] It is important to note that, in our study, particle size of the microsphere was directly proportional to the concentration of CH used and at high concentration clusters of microspheres were observed.…”

Section: Physicochemical Characterization Of Microspheresmentioning

confidence: 99%

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Taksande¹

2017

AJP

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Aim: Due to the presence of rich blood circulation and non-invasive nature of administration, the nasal route has been established as valuable therapeutic alternatives. This study was designed with the basic objective to formulate mucoadhesive microspheres of anticonvulsant drug, lamotrigine (LT) for intranasal delivery and to carry out its pharmacodynamic investigations to benefit the emergency cases of epileptic seizures. Materials and Methods:The microspheres were prepared by ionotropic gelation method and characterized for morphology scanning electron microscopy, particle size, drug entrapment efficiency, thermal behavior (differential scanning calorimetry), and crystallinity (X-ray diffraction), in vitro swelling studies, in vitro drug diffusion, ex vivo bioadhesion, and ex vivo biocompatibility studies in excised sheep nasal mucosa. The resultant LT loaded chitosan (CH) microspheres were further evaluated for pharmacodynamic efficacy in pentylenetetrazol (PTZ) induced seizures in mice. Result and Discussion: Results demonstrated that the microspheres were discrete, smooth, and spherical in shape with size 24.5 ± 2.62 to 48.52 ± 2.34 µm, appropriate for nasal drug delivery. The CH-based nasal LT microspheres demonstrated high encapsulation efficacy, strong bioadhesion potential, and high permeation without any signs of morphological toxicity in excised sheep nasal mucosa. Importantly the intranasal administration of LT microspheres delayed the onset of clonic convulsion and offered complete protection against the PTZ induced seizures in mice compared to its peripheral administration. Conclusion: Thus, the formulation of LT loaded CH mucoadhesive microspheres offers promising advantages over conventional dosage with its immediate onset of action.

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“…To combat with mucociliary clearance, mucoadhesive polymers like chitosan Hafner et al, 2007;Gungor et al, 2010b), gelatin (Wang et al, 2006), alginates , etc., are included during formulation resulting in longer contact time for better absorption of drugs.…”

Section: Microspheresmentioning

confidence: 99%

Nasal-nanotechnology: revolution for efficient therapeutics delivery

2014

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Context: In recent years, nanotechnology-based delivery systems have gained interest to overcome the problems of restricted absorption of therapeutic agents from the nasal cavity, depending upon the physicochemical properties of the drug and physiological properties of the human nose. Objective: The well-tolerated and non-invasive nasal drug delivery when combined with the nanotechnology-based novel formulations and carriers, opens the way for the effective systemic and brain targeting delivery of various therapeutic agents. To accomplish competent drug delivery, it is imperative to recognize the interactions among the nanomaterials and the nasal biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signaling involved in patho-biology of the disease under consideration. Methods: Quite a few systems have been successfully formulated using nanomaterials for intranasal (IN) delivery. Carbon nanotubes (CNTs), chitosan, polylactic-co-glycolic acid (PLGA) and PLGA-based nanosystems have also been studied in vitro and in vivo for the delivery of several therapeutic agents which shown promising concentrations in the brain after nasal administration. Results and conclusion: The use of nanomaterials including peptide-based nanotubes and nanogels (NGs) for vaccine delivery via nasal route is a new approach to control the disease progression. In this review, the recent developments in nanotechnology utilized for nasal drug delivery have been discussed.

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Ondansetron-loaded chitosan microspheres for nasal antiemetic drug delivery: an alternative approach to oral and parenteral routes

Abstract: Based on in vitro and in vivo data, it could be concluded that crosslinked chitosan microspheres are considered as a nasal delivery system of OND.

Cited by 32 publications

References 29 publications

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Nasal-nanotechnology: revolution for efficient therapeutics delivery

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