Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

Leksowski, Krzysztof; Peryga, P.; Szyca, Robert

doi:10.1007/s00464-005-0622-7

Cited by 51 publications

(53 citation statements)

References 21 publications

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“…Combination antiemetic therapy with serotonin antagonists (granisetron, ondansetron, tropisetron) plus dexamethasone, metoclopramide, or droperidol is known to be highly effective in preventing PONV [2,13,[31][32][33][34]. We did not use this combination therapy in the current study because there was no need to apply PCA, including opioids.…”

Section: Discussionmentioning

confidence: 81%

“…Numerous studies have investigated the prevention and treatment of PONV for patients scheduled to undergo LC using a variety of antiemetics including anticholinergics [8,9], antihistamines [10], phenothiazines [11], butyrophenones [12], and benzamide [6,13]. However, these agents may cause undesirable adverse effects such as excessive sedation, hypotension, dry mouth, dysphoria, hallucinations, and extrapyramidal signs [14].…”

Section: Introductionmentioning

confidence: 99%

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Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Ryu

Hwang

et al. 2009

Surg Endosc

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Ryu

Hwang

et al. 2009

Surg Endosc

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“…Nausea and vomiting are the most common causes of postoperative complications, and they are seen most often after operations performed using general anesthesia and sedation [1,2]. Postoperative nausea and vomiting (PONV) are associated with gender, age, weight, anxiety, smoking, agents used for anesthesia, duration of anesthesia, and type of surgery (particularly gynecological and pelvic operations) [3,4].…”

Section: Introductionmentioning

confidence: 99%

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

Ekinci

Malat

Işıtmangil

et al. 2010

Gynecol Obstet Invest

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Background: Nausea and vomiting are the most common causes of postoperative complications, and they are seen most often after operations performed using general anesthesia and sedation. We designed this study to compare the effects of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic operations. Methods: One hundred patients were randomly assigned to 1 of 5 groups: group D was given 2.5 mg droperidol; group M, 10 mg metoclopramide; group T, 2.5 mg tropisetron; group O, 4 mg ondansetron 5 min after induction, and group C was the control group and received no prophylactic antiemetic treatment. All patients were observed for sedation and postoperative nausea and vomiting for 48 h. Results: Within 24 h after the operation, severe postoperative nausea and vomiting were seen in 4 patients (20%) in group D, 8 (40%) in group M, 5 (25%) in group T, 3 (15%) in group O, and 12 patients (60%) in the control group. Patients receiving droperidol, tropisetron, and ondansetron had significantly less serious emesis than the control group (p < 0.05). Sedation was seen in 5 patients receiving droperidol (4 patients score 2; and 1 patient score 3) and tropisetron (2 patients score 2; and 3 patients score 3) 15 min after surgery; this was significantly higher than in the control group (p < 0.05). Conclusion: We conclude that metoclopramide is not effective in preventing postoperative nausea and vomiting after gynecologic operations. Droperidol, tropisetron, and ondansetron are effective; however, the sedating effects of droperidol and tropisetron should be considered.

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“…In laparoscopic methods the tissue injury is less than open surgeries but still post-operative nausea and vomiting (PONV) are among common complications, and its prevalence has been reported in different studies about 44%-83% (1, 2). PONV can lead to sweating, tachycardia, abdominal pain, prolonged recovery duration and increased risk of aspiration (3). The etiology of PONV is not still known well, but it is probably a multifactorial phenomenon (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…Previously, anti-cholinergics, anti-histamines and phenothiazines were used to prevent PONV (8); but low effect of these medications and their complications led to drug shifts. Recent studies have shown that serotonin receptor antagonists are more effective than previous medications in PONV prophylaxis (3,9). It has been proved that Granisetron and Ondansetron are effective medications in this field (9) but by considering the high price of these drugs, suitable substitutes are required.…”

Section: Introductionmentioning

confidence: 99%

Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy

Hessami

Yari²

2012

anesthpain

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Dexamethasone is a low price corticosteroid which has anti-inflammatory effects. This article help us to find a cost effective drug for prophylaxis of PONV.Background: Post-operative nausea and vomiting (PONV) is one of the common problems after laparoscopic cholecystectomy. Objectives: The current study aimed to compare Dexamethasone effect with that of Granisetron in prevention of PONV. Patients and Methods: In the current study 104 patients aged 20-60 with ASA class I or II who were candidates for laparoscopic cholecystectomy were included in the study. Patients were randomly divided into two groups of A and B. 15 minutes before anesthesia induction, in group a patient's 3 mg Granisetron and in group B patients 8 mg Dexamethasone was intravenously injected. Then both groups underwent general anesthesia with similar medications. After operation the prevalence of nausea and vomiting was assessed at three time intervals (0-6 hours, 6-12 hours and 12-24 hours after consciousness). SPSS software version 16 was employed to analyze data. T test, chi-square test and Fischer exact test were performed level of significance was P < 0.05. Results: There was no significant difference between age, gender proportion, weight, height, and body mass index (BMI) of patients in the two groups. In Dexamethasone group, seven patients experienced nausea and three patients had vomiting, and in Granisetron group, five patients experienced nausea and three patients had vomiting after consciousness. Statistical analysis indicated no significant difference between the two groups in this regard. Conclusions: Intravenous injection of 8 mg Dexamethasone or 3 mg Granisetron before anesthesia induction had similar effects in prophylaxis of nausea and vomiting after laparoscopic cholecystectomy.

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Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

Abstract: Administration of antiemetic drugs significantly decreases the incidence of PONV in patients after laparoscopic cholecystectomy. The best decreases were achieved when ondansetron and dexamethason were applied together.

Cited by 51 publications

References 21 publications

Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy

A Randomized Comparison of Droperidol, Metoclopramide, Tropisetron, and Ondansetron for the Prevention of Postoperative Nausea and Vomiting

Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy

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