Ondine’s curse: the origin of the myth

Orrego-González, Eduardo; Medina-Rincón, Germán José; Martínez-Gil, Sofía; Botero-Meneses, Juan Sebastián

doi:10.1590/0004-282x20190162

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…Its prevalence is estimated at 2.79 cases per 100 000 men as per a population-based epidemiology study . To our knowledge, this is the first description of trismus and sleep-related central hypoventilation (also known as Ondine’s curse) associated with KLHL11 autoimmunity. This is also the first report of KLHL11-IgG associated with a symmetric, dorsal brainstem lesion extending from the midbrain to the medulla.…”

mentioning

confidence: 77%

Ondine’s Curse and Trismus in Association With Kelch-like Protein-11 Autoimmunity

Devine

Dubey

2021

JAMA Neurol

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mentioning

confidence: 77%

Ondine’s Curse and Trismus in Association With Kelch-like Protein-11 Autoimmunity

Devine

Dubey

2021

JAMA Neurol

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“…Sudden death has also been reported with COVID-19, although this has been most often attributed to cardiac disease 37 . These symptoms suggest the possibility of central hypoxia or Ondine’s curse 38 . However, to date, objective evidence is lacking.…”

Section: Neurologic Complications Of Covid-19mentioning

confidence: 99%

“…37 These symptoms suggest the possibility of central hypoxia or Ondine's curse. 38 However, to date, objective evidence is lacking. Autopsy studies suggest that the pathology is particularly prominent in the olfactory system and the brainstem.…”

Section: Key Pointsmentioning

confidence: 99%

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Nath¹

2021

CONTINUUM: Lifelong Learning in Neurology

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PURPOSE OF REVIEW: This article describes the spectrum of neurologic complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, their underlying pathology and pathogenic mechanisms, gaps in knowledge, and current therapeutic strategies.RECENT FINDINGS: COVID-19 is the clinical syndrome caused by the novel coronavirus SARS-CoV-2. It can affect the entire neuraxis, and presentations in the acute phase are variable, although anosmia is a common manifestation. Encephalopathy is common in patients who are hospitalized and is often associated with multiorgan involvement. Immune-mediated encephalitis is probably underrecognized; however, viral encephalitis is rare. Other manifestations include stroke, seizures, myelitis, and peripheral neuropathies, including Guillain-Barré syndrome, which sometimes has atypical manifestations. Treatment is symptomatic, and immunotherapies have been used successfully in some patients. Long-term complications include dysautonomia, exercise intolerance, malaise, sleep disturbances, cognitive impairment, and mood disorders. SUMMARY: Neurologic manifestations of COVID-19 may occur in the acute setting and may be independent of respiratory manifestations. Immune-mediated syndromes and cerebrovascular complications are common. Large populations of patients are expected to have long-term neurologic complications of COVID-19, many of which may emerge only after recovery from the acute illness.

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“…A single moment of inattention and I forget to breathe. He died, they will say, because it was a nuisance to breath…’ [10–14].…”

Section: The Brain-respiration Connection In Other Childhood-onset Il...mentioning

confidence: 99%

Sudden unexpected death in children: myth or reality?

Enner

Pavkovic

Kothare

2021

Current Opinion in Pediatrics

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Purpose of review Despite many years of study, sudden unexplained death remains a tenuous diagnosis of exclusion. Here, we discuss the current science behind the uncertainties of sudden death, as well as the questions that still remain. Recent findings Failure in any part of the complex interplay between peripheral sensors and central cardiorespiratory regulation can result in sudden death. Diagnostic testing with electrocardiograms, electroencephalogram, sleep studies, or even genetic studies have increased our ability to identify patients at the highest risk. Summary Advances in the understanding of sudden unexplained death in children may show common pathways leading to sudden death from multiple different diseases. Although rare, the devastating implication prioritizes the importance in educating patients about how to live with the risk of sudden death.

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Ondine’s curse: the origin of the myth

Cited by 7 publications

References 10 publications

Ondine’s Curse and Trismus in Association With Kelch-like Protein-11 Autoimmunity

Ondine’s Curse and Trismus in Association With Kelch-like Protein-11 Autoimmunity

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Sudden unexpected death in children: myth or reality?

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