2020
DOI: 10.3389/fphys.2020.00099
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One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila

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Cited by 31 publications
(25 citation statements)
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References 172 publications
(249 reference statements)
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“…Following the last reported, CRYs are the best candidate for biochemical magnetoreceptor that mediate light-dependent magnetosensitivity with radical-pair reaction, which associated with FAD¯° binding to CRY-photoreceptor proteins 16,19 . Furthermore, some recent experiments revealed that radical pair formation in the mammalian-type CRYs can occurs during magnetosensitivity by molecular oxygen and is not dependent to light [60][61][62] . CRYs can implicate to reinnervation and repairing of nervous systems in the mammalian brain as light-independent magnetosensor by an external low intensity EMF stimulations 63 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Following the last reported, CRYs are the best candidate for biochemical magnetoreceptor that mediate light-dependent magnetosensitivity with radical-pair reaction, which associated with FAD¯° binding to CRY-photoreceptor proteins 16,19 . Furthermore, some recent experiments revealed that radical pair formation in the mammalian-type CRYs can occurs during magnetosensitivity by molecular oxygen and is not dependent to light [60][61][62] . CRYs can implicate to reinnervation and repairing of nervous systems in the mammalian brain as light-independent magnetosensor by an external low intensity EMF stimulations 63 .…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, circadian system can protects tumor cells from chemotherapeutics. Therefore, CRYs play a pleiotropic role in the cells such related to p53 activity and cell cycle progression, and also DNA damage pathways, etc 62,68 .…”
Section: Discussionmentioning
confidence: 99%
“…The subsequent degradation of TIM leads to clock resetting (Koh et al., 2006; Lin et al., 2001; Naidoo, Song, Hunter‐Ensor, & Sehgal, 1999). Cry KO flies are resistant to light‐induced phase shifting, as well as free‐running in constant light conditions (Damulewicz & Mazzotta, 2020; Krishnan et al., 2001; Stanewsky et al., 1998; Tataroglu & Emery, 2015). Mutants of jet on the other hand, show no alterations in phenotypes in either light conditions or DD.…”
Section: Ubiquitination and Deubiquitination In The Clock Of Drosophilamentioning
confidence: 99%
“…Cryptochrome (CRY) is a blue-light-sensitive protein ( VanVickle-Chavez and Van Gelder, 2007 ) playing many different roles, ranging from photoreceptor to magnetoreception and metabolism regulation (for review see Damulewicz and Mazzotta, 2020 ). It is expressed in a broad range of cells in the brain: in circadian pacemaker neurons (all five s-LNvs, l-LNvs, three of the six LNds, and some of the DN1s), but also in non-clock neurons, glia and visual system ( Benito et al, 2008 ; Yoshii et al, 2008 ; Damulewicz and Pyza, 2011 ; Fogle et al, 2011 ).…”
Section: How Do Light Inputs Modulate Sleep In Drosophila mentioning
confidence: 99%