One anastomosis gastric bypass and esojejunostomy in rats: surgical techniques

Abstract

One anastomosis gastric bypass (OAGB) is a popular bariatric procedure, but controversies remain regarding biliary reflux and the potential risk of cancer. Esophagojejunostomy (EJ) in rats is a validated and reproducible model for the development of metaplasia [Barett's esophagus (BE)] and esophageal adenocarcinoma (EA) with a minimal exposure of 12 to 20 weeks. We are analyzing the risks of BE and EA in an OAGB rat model and comparing these with the EJ rat model. The purpose of this study is to describe our OAGB and EJ techniques in rats that we used to evaluate biliary reflux and share our experience with scientists and the bariatric community. These operations are short and simple procedures with acceptable morbidity.

Metabolic and bariatric surgery

“…However, other procedures such as the one anastomosis gastric bypass (OAGB) have been growing in popularity despite the concern for bile reflux. The Paris Descartes Faculty of Medicine studied reflux, Barrett's esophagus, and esophageal cancer [6] . They shared their findings and concluded that the OAGB operation appears to be safe in an animal model.…”