One and twelve month safety and efficacy outcomes of patients undergoing edge-to-edge percutaneous mitral valve repair: the GRASP registry

Grasso, Carmelo; Capodanno, Davide; Scandura, Salvatore; Cannata, Stefano; Immè, Sebastiano; Mangiafico, Sarah; Pistritto, Anna Maria; Ministeri, Margherita; Giaquinta, Sandra; Tamburino, C

doi:10.1093/eurheartj/eht310.p5377

Cited by 38 publications

(81 citation statements)

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“…As in previous studies, clip embolization was not observed in the present registry. In fact, only a single case of clip embolization has been reported worldwide, so far [1,[3][4][5]8,[16][17][18][19][20][21][22][23][24][25][26][27][28][29] (Table V). Partial clip detachment from one leaflet was rarely observed (2% in the present analysis) and occurred spontaneously or during advancement of a second clip for residual MR.…”

Section: Discussionmentioning

confidence: 99%

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Risk and outcomes of complications during and after MitraClip implantation: Experience in 828 patients from the German TRAnscatheter mitral valve interventions (TRAMI) registry

Eggebrecht

Schelle

Puls³

et al. 2015

Cathet Cardio Intervent

112

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Aims: To analyze risk and outcomes of complications during and after MitraClip implantation using multicenter data from the prospective German Transcatheter Mitral Valve Interventions (TRAMI) registry. Methods and Results: Data of 828 patients (mean age: 76.0 [71-81] years, 327 (40%) females) undergoing MitraClip implantation in Germany between 2010 and 2013 were analyzed. Most patients (85%) underwent elective procedures with on average implantation of 1.4 6 0.6 clips. Emergent cardiac surgery was not required; a single patient died intraoperatively. During the in-hospital period, complications occurred in 215 (25.9%) patients, of which 106 (12.8%) were considered major. Major bleeding complications were among the most frequent major complications (7.4%), while rates of pericardial tamponade (1.9%) and clip-specific complications (embolization: 0%, partial clip detachment: 1.9%) were low. In-hospital death, stroke or myocardial infarction (MACCE) occurred in 2.2, 0.9, and 0% patients, respectively. Patients with complications appeared to be older and more critically ill preinterventionally; in-hospital mortality was significantly higher as compared to those without procedural complications. Conclusions: MitraClip implantation appears to be a safe treatment option with low rates of MACCE and clip-specific complications. Catheterization and Cardiovascular Interventions 86: 728-735 (2015) Nevertheless, MitraClip therapy is not without complications. Careful patient selection and improvements in preventing peri-procedural bleeding have the potential of reducing post-procedural complications and improving outcomes. V C 2015 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies suggested that the MitraClip procedure is safe [1]. Rates of procedure-related major adverse events ranged between 0 and 4.3% [3,4]. In fact, in the randomized EVEREST II-trial, MitraClip implantation was superior over conventional surgical valve repair with respect to procedural safety [5].…”

Section: Introductionmentioning

confidence: 99%

Risk and outcomes of complications during and after MitraClip implantation: Experience in 828 patients from the German TRAnscatheter mitral valve interventions (TRAMI) registry

Eggebrecht

Schelle

Puls³

et al. 2015

Cathet Cardio Intervent

112

View full text Add to dashboard Cite

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“…The Getting Reduction of Mitral Insufficiency by Percutaneous Clip Implantation (GRASP) registry showed freedom from the composite endpoint of death, surgery, or MR grade 3+ in 75.8% of 117 treated patients at 1 year [5].These data also did not show any differences in safety or outcomes when comparing patients with degenerative vs functional MR. A recent meta-analysis reviewing 16 studies confirmed a low adverse event rate and only 14.7% of patients demonstrating MR grade 3+ at 1 year [6]. The largest series of treated patients (749 patients with 1-year follow-up from the German transcatheter mitral valve interventions registry) demonstrated 79.7% 1-year survival among all patients, as well as a decreased rate of hospital readmission for heart failure [7].…”

Section: Studiesmentioning

confidence: 91%

Treatment of mitral regurgitation

Violini

Cifarelli

Felice

et al. 2017

Monaldi Arch Chest Dis

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In the elderly mitral regurgitation is very frequent and surgical correction of mitral regurgitation (MR) has often a high operative risk, consequently, over the years, different percutaneous transcatheter techniques have been developed as a valid alternative to surgery. The edge-to-edge repair with the MitraClip device has gained a wide clinical application, supported by several studies, both randomized trials and registries. It is indicated in functional MR as in degenerative MR. The outcome is usually positive, resulting in a reduction of the regurgitation to grade 1+ or 2+ and an improvement in the NYHA functional class to I or II, even reducing the hospitalizations. Its cost-effectiveness too is supported by some studies.

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“…[16][17][18][19][20][21][22][23][24][25][26][27] A recent pooled analysis of 351 patients in the EVEREST II High Risk Registry and the REALISM (Real World Expanded Multi-center Study of the MitraClip System) Continued Access Study demonstrated an implantation success of 96%. 19 These patients were all considered high risk for surgery (estimated Society of Thoracic Surgeons score >12%).…”

Section: Evidence From Registriesmentioning

confidence: 99%

Current Status and Clinical Development of Transcatheter Approaches for Severe Mitral Regurgitation

Grasso

Capodanno

Tamburino

et al. 2015

Circ J

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Transcatheter mitral valve intervention has emerged as an effective treatment option for symptomatic severe mitral regurgitation in patients considered to be inoperable or at high operative risk for surgical mitral valve surgery. Most transcatheter approaches are modifications of existing surgical approaches. Transcatheter edge-to-edge mitral valve repair with the MitraClip system has the largest clinical experience to date, as it offers a sustained clinical benefit in selected patients. This review aims to provide an up-to-date overview of transcatheter mitral valve interventions, including leaflet repair, annuloplasty, and mitral valve implantation. (Circ J 2015; 79: 1164 -1171

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One and twelve month safety and efficacy outcomes of patients undergoing edge-to-edge percutaneous mitral valve repair: the GRASP registry

Cited by 38 publications

References 0 publications

Risk and outcomes of complications during and after MitraClip implantation: Experience in 828 patients from the German TRAnscatheter mitral valve interventions (TRAMI) registry

Risk and outcomes of complications during and after MitraClip implantation: Experience in 828 patients from the German TRAnscatheter mitral valve interventions (TRAMI) registry

Treatment of mitral regurgitation

Current Status and Clinical Development of Transcatheter Approaches for Severe Mitral Regurgitation

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