One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation

Francioso, Antonio; Conrado, Alessia Baseggio; Blarzino, Carla; Foppoli, Cesira; Montanari, Elita; Dinarelli, Simone; Giorgi, Alessandra; Mosca, Luciana; Fontana, Mario

doi:10.3390/molecules25040961

Cited by 17 publications

(19 citation statements)

References 68 publications

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“…In addition, the bicarbonate/carbon dioxide pair cannot stimulate one-electron oxidation mediated by a carbonate radical anion (CO 3 ●− ), which efficiently oxidizes the thioether sulfur of the Met residue to sulfoxide. CO 3 ●− causes the one-electron oxidation of methionine residue to sulfur radical cation (MetS ●+ ) [ 86 ]. Though COVID-19 patients exhibit neurological signs and symptoms, the histopathological examination of brain specimens only shows hypoxic changes, and not encephalitis or other specific brain changes that can be related to the virus.…”

Section: Discussionmentioning

confidence: 99%

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

Lee

Sohn

et al. 2020

IJMS

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The aim of this study is to examine the use of an inflammasome competitor as a preventative agent. Coronaviruses have zoonotic potential due to the adaptability of their S protein to bind receptors of other species, most notably demonstrated by SARS-CoV. The binding of SARS-CoV-2 to TLR (Toll-like receptor) causes the release of pro-IL-1β, which is cleaved by caspase-1, followed by the formation and activation of the inflammasome, which is a mediator of lung inflammation, fever, and fibrosis. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is implicated in a variety of human diseases including Alzheimer’s disease (AD), prion diseases, type 2 diabetes, and numerous infectious diseases. By examining the use of 4,4′-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen’s disease, also diagnosed as Alzheimer’s disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. TLRs, due to genetic polymorphisms, can alter the immune response to a wide variety of microbial ligands, including viruses. In particular, TLR2Arg677Trp was reported to be exclusively present in Korean patients with lepromatous leprosy (LL). Previously, mutation of the intracellular domain of TLR2 has demonstrated its role in determining the susceptibility to LL, though LL was successfully treated using a combination of DDS with rifampicin and clofazimine. Of the three tested antibiotics, DDS was effective in the molecular regulation of NLRP3 inflammasome activators that are important in mild cognitive impairment (MCI), Parkinson’s disease (PD), and AD. The specific targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS may be responsible for its observed preventive effects, functioning as a competitor.

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Section: Discussionmentioning

confidence: 99%

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

Lee

Sohn

et al. 2020

IJMS

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“…The bicarbonate/carbon dioxide pair stimulates one-electron oxidation. Carbonate-radical anions (CO3 •ㅡ ) mediate one-electron reactions that promote one-electron oxidation that efficiently oxidizes Met residue thioester sulfur to radical sulfur cations (MetS •+ ) (145). Dapsone has a structure that can competitively reduce the production of the positively charged sulfur radical because it is similar to methionine sulfoxide (16).…”

Section: Dapsone Competitively Inhibits Inflammasomesmentioning

confidence: 99%

Pathology and Anticatalysis treatment of exacerbated COVID-19

Lee¹,

Cho²,

Kanwar³

et al. 2022

Preprint

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated inflammasome diseases. Moreover, its pathophysiology involves the angiotensin-converting enzyme 2 (ACE2) receptor, Toll-like receptor 4 (TLR4) pathway, neuropilin‑1 pathway, inflammasome activation pathway, sterile alpha motif (SAM) and histidine-aspartate domain (HD)-containing protein 1 (SAMHD1) tetramerization pathway, cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway, spike protein/inflammasome-genetic pathway, and immunological memory engram pathway. Therefore, it is necessary to prescribe anticatalytic treatments to alleviate the SARS-CoV-2 inflammasome, immunologic engram, and spike protein levels.

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“…The bicarbonate/carbon dioxide pair stimulated One-electron oxidations. Carbonate radical anions (CO 3 • ) mediate one-electron reactions to promote one-electron oxidation to e ciently oxidize thioether sulfur of the Met residue to sulfur radical cations (MetS •+ ) 28 . DDS has a structure that can competitively reduce the positively charged sulfur radical production rate because it has a similar structure to methionine sulfoxide.…”

Section: Dds In Neuroin Ammatory Focimentioning

confidence: 99%

The Preventive and Treatment of the Neuro-Inflammasome in Sorokdo National Hospital

Lee

Lee²,

Park

et al. 2021

Preprint

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Aim/Background: This study investigated patients with Alzheimer's disease (AD) treated with 4,4’-diaminodiphenyl sulfone (DDS) as a neuro-inflammasome competitor. Method: The Seoul study analyzed AD, and anti-AD drugs (AADs) in the Sorokdo National Hospital's EDI database archived from January 2005 to June 2020 through the ICD-9 and -10 codes. Result: DDS acts as a neuro-inflammasome competitor; this effect can be inferred by comparing the prevalence of AD in patients who have been prescribed DDS and those who have not. Conclusion: This study suggests the use of neuro-inflammasome therapy as a preventive and therapeutic method for AD.

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One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation

Cited by 17 publications

References 68 publications

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

Pathology and Anticatalysis treatment of exacerbated COVID-19

The Preventive and Treatment of the Neuro-Inflammasome in Sorokdo National Hospital

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