One‐Carbon Homologation and Homologation–Functionalization Reactions of Aldehydes

Gold(i)-catalyzed homologation of aryl aldehydes with trimethylsilyldiazomethane

“…Homologation of carbonyl compounds is a sought-after transformation in organic chemistry since they are versatile synthetic building blocks. 1,2 More specifically, the homologation of aryl aldehydes to form 2-aryl acetaldehydes allows the conversion of aryl aldehyde feedstocks into synthetically useful heterocyclic intermediates. [3][4][5] Although a vast number of aliphatic aldehydes are commercially available, simple 2-aryl acetaldehydes are rare.…”