One Degree of Freedom 7-R Closed Loop Linkage as a Building Block of Nanorobots

Chorsi, Meysam T.; Tavousi, Pouya; Mundrane, Caitlyn; Gorbatyuk, Vitaliy; Ilieş, Horea T.; Kazerounian, Kazem

doi:10.1007/978-3-030-50975-0_6

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Piezoelectric materials, a type of "smart" material that can convert mechanical force into electricity and vice versa, are the core of many medical devices, including pressure sensors, actuators, and ultrasonic transducers (1)(2)(3)(4)(5)(6)(7). In many cases, these devices are implanted inside the body for various applications, such as monitoring intraorgan pressures, generating ultrasound (US) to facilitate drug delivery, ablating diseased tissues, and/or stimulating tissue healing (8)(9)(10)(11)(12)(13). An appealing potential of these piezoelectric devices is their ability to be self-powered by harvesting the body's own motion and thus avoiding the use of toxic batteries often required for medical implants (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications

Chorsi,

Le,

Lin

et al. 2023

Sci. Adv.

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Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.

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