One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model

Fort, María; Sibila, Marina; Pérez-Martín, Eva; Nofrarías, Miquel; Mateu, Enric; Segalés, Joaquím

doi:10.1016/j.vaccine.2009.04.028

Cited by 158 publications

(133 citation statements)

References 26 publications

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“…Currently, several PCV2 vaccines designed for immunization of sows or piglets have been registered. Several studies proved that all vaccines give very good results with respect to limiting losses due to PCVD (Kixmoller et al 2008, Fort et al 2009). In herds where losses associated to PCVD affect mainly growers and finishers vaccination of piglets should be applied (Cline et al 2008, Horlen et al 2008, Pejsak et al 2010.…”

Section: Introductionmentioning

confidence: 99%

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Pejsak¹,

Kusior²,

Pomorska‐Mól³

et al. 2012

Polish Journal of Veterinary Sciences

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The objective of the study was to evaluate an efficacy of sows vaccination protocols in the herd with serious problems affecting efficacy of reproduction. The study was performed in a large pig herd with about 1200 sows. Before vaccination against PCV2, farrowing rate in this farm was about 65%.Sows, boar and replacement gilts were immunized using Circovac vaccine (Merial, France) according to producer's recommendations. Parameters of production were analyzed since 2007 until 2010 in selected batches of sows inseminated at the same weeks of the year (17th, 18th, 19th and 20th) to eliminate seasonal variability. In total, 940 sows were subjected to the study. No significant changes in management during these years were introduced.The applied protocol of sow herd long-term vaccination proved to be very efficient. All measured production parameters: reproduction rate, number of piglets born alive, birth weight of piglets and number of piglets weaned per a litter improved after implementation of immunization program. Moreover, further improvement was observed with vaccination in the following reproduction cycles. The most spectacular effect of vaccination regarded average farrowing rate that increased from 64.76% in control group to 86.93% after basic vaccination. Two years after implementation of vaccination program this parameter reached 93.6%. Number of piglets weaned per sow per a litter improved from 10.31 to 11.74 after one year of vaccination and remained relatively stable through the following year. Simultaneously, the percentage of newborn piglets with birth weight < 1 kg decreased significantly (p < 0.05).To summarize, vaccination against PCV2 influenced positively the insemination rate, number of piglets born alive and weaned per litter as well as birth body weight and percentage of piglets weighing < 1 kg.

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Section: Introductionmentioning

confidence: 99%

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Pejsak¹,

Kusior²,

Pomorska‐Mól³

et al. 2012

Polish Journal of Veterinary Sciences

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“…PCV2 vaccines decrease the PCV2 load in the serum and reduce PCV2 shedding in nasal and fecal samples in conventional pigs (5). Commercial vaccines were shown to be able to control two of the multiple disease entities, known as PMWS and PRDC (2,4,5,16,18). To our knowledge, this is the first application of a PCV2 vaccine in boars to determine its effect on PCV2 shedding in the semen.…”

Section: Discussionmentioning

confidence: 92%

“…Therefore, the inactivated PCV2 vaccine was used in an extralabel manner to determine its effect against PCV2 shedding in semen from experimentally infected boars. The reduction in the PCV2 load is one of the criteria used to assess the efficacy of PCV2 vaccines (5,15). PCV2 vaccines decrease the PCV2 load in the serum and reduce PCV2 shedding in nasal and fecal samples in conventional pigs (5).…”

Section: Discussionmentioning

confidence: 99%

“…The reduction in the PCV2 load is one of the criteria used to assess the efficacy of PCV2 vaccines (5,15). PCV2 vaccines decrease the PCV2 load in the serum and reduce PCV2 shedding in nasal and fecal samples in conventional pigs (5). Commercial vaccines were shown to be able to control two of the multiple disease entities, known as PMWS and PRDC (2,4,5,16,18).…”

Section: Discussionmentioning

confidence: 99%

“…All PCV2 vaccines have been administered to either sows or piglets (2,5,16,18). Commercial PCV2 vaccines are able to reduce the PCV2 load in the serum and reduce PCV2 shedding in nasal and fecal samples in conventional pigs (5,15,16,18).…”

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confidence: 99%

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Effects of an Inactivated Porcine Circovirus Type 2 (PCV2) Vaccine on PCV2 Virus Shedding in Semen from Experimentally Infected Boars

Seo

Han

Kim

et al. 2011

Clin. Vaccine Immunol.

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The objective of the present study was to determine the effect of an inactivated porcine circovirus type 2 (PCV2) vaccine on PCV2b virus shedding in the semen of experimentally infected boars by measuring the immunological response and the PCV2b DNA load in blood and semen. Twelve boars were randomly divided into three groups. The boars in group 1 (n ‫؍‬ 4) were immunized with an inactivated PCV2 vaccine and were challenged with PCV2b. The boars in group 2 (n ‫؍‬ 4) were only challenged with PCV2b. The boars in group 3 (n ‫؍‬ 4) served as negative controls. The number of PCV2 genome copies of PCV2 in the serum and semen were significantly lower in vaccinated challenged boars than in nonvaccinated challenged boars at 7, 10, 14, 21, 32, 35, 42, 49, and 60 days postinoculation. The number of PCV2b genomes in the semen correlated with the number of PCV2b genomes in the blood in both vaccinated challenged (R ‫؍‬ 0.714) and nonvaccinated challenged (R ‫؍‬ 0.861) boars. The results of the present study demonstrate that the inactivated PCV2 vaccine significantly decreases the amount of PCV2b DNA shedding in semen from vaccinated boars after experimental infection with PCV2b.Porcine circovirus type 2 (PCV2) is associated with a number of diseases and syndromes collectively referred to as porcine circovirus-associated disease (PCVAD), which includes postweaning multisystemic wasting disease (PMWS), porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, porcine respiratory disease complex (PRDC), and exudative epidermitis (3).Several commercial PCV2 vaccines are currently available in the global market. All PCV2 vaccines have been administered to either sows or piglets (2,5,16,18). Commercial PCV2 vaccines are able to reduce the PCV2 load in the serum and reduce PCV2 shedding in nasal and fecal samples in conventional pigs (5,15,16,18). Recently, it has also been reported that vaccination against PCV2 in naturally infected boars can decrease the duration of viral shedding in semen (1). These data strongly imply that vaccination against PCV2 may reduce the subsequent shedding of PCV2 in the semen of boars. Therefore, the objective of the present study was to determine the effect of PCV2 vaccination on the shedding of the PCV2 virus in the semen of experimentally infected boars. MATERIALS AND METHODSCommercial vaccine and PCV2 inoculum. The commercial inactivated tissue homogenate PCV2 vaccine based on PCV2 genotype 2b, CircoPrime (Komipharm International Company Ltd., Shiheung-shi, Kyongki-do, Republic of Korea), was used in this study. It was administered intramuscularly in two 2.0-ml doses separated by 3 weeks.The PCV2 strain (PCV2 genotype b) isolated from the superficial inguinal lymph node of a field case of PMWS was used as the inoculum. The virus was propagated in PCV-free PK15 cells to a titer of 10 5 50% tissue culture infective doses (TCID 50 s)/ml.Experimental design. At 8 months of age, 12 purebred, male, Landrace pigs were purchased from a commercial farm. All boars were negative for PCV2 and...

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Circoviruses

Segalés¹,

Allan²,

Domingo³

2019

Diseases of Swine

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One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model

Cited by 158 publications

References 26 publications

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Effects of an Inactivated Porcine Circovirus Type 2 (PCV2) Vaccine on PCV2 Virus Shedding in Semen from Experimentally Infected Boars

Circoviruses

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