One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates

Abstract

One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates.

Surgical antibiotic practices among pediatric urologists in the United States

“…A meta-analysis of aminoglycoside dosing in children concluded that extended interval dosing was associated with lower costs, simpler administration regimens, and similar or superior efficacy and safety outcomes as compared to multiple daily dosing [24]. Furthermore, a Cochrane review of gentamicin dosing in septic neonates reported that extended interval dosing featured improved pharmacokinetics and similar toxicity and efficacy versus multiple daily dosing [25]. Despite the high-level evidence favoring extended interval dosing, only 6.9% of surveyed urologists who employ gentamicin for surgical prophylaxis (78.7% of all respondents) use >3.5 mg/kg.…”

Clinical practice guidelines for antimicrobial prophylaxis in surgery

“…16 This dose of gentamicin has been found safe and effective in a large body of literature examining the use of single daily doses of gentamicin for therapeutic indications. [106][107][108][109][110][111][112][113] When used as a single dose for prophylaxis, the risk of toxicity from gentamicin is very low.…”

Drug-induced acute kidney injury in neonates

“…In an effort to maximize therapeutic benefits and minimize toxicity, extended interval AG dosing regimens have been adopted. Extended interval dosing is recommended based on favorable pharmacokinetics, but has yet to be shown to impact rates of nephrotoxicity in neonates [37]. …”