One Health Approach for Reporting Veterinary Carbapenem-Resistant Enterobacterales and Other Bacteria of Public Health Concern

Abstract

A carbapenem-resistant Enterobacterales outbreak at a veterinary teaching hospital in the United States increased urgency for improved communication among diagnostic laboratories, public health authorities, veterinarians, and pet owners. Kansas State University, University of Missouri, Kansas Department of Health and Environment, and Veterinary Laboratory Investigation and Response Network created a surveillance, storage, and reporting protocol for veterinary antimicrobial-resistant bacteria; determined frequency of those bacteria in companion animals during 2018–2021; and created educational flyers for veterinarians and pet owners. We recommend a One Health strategy to create efficient surveillance programs to identify and report antimicrobial-resistant bacteria and educate veterinarians and pet owners about transmission risks.

Prevalence and molecular epidemiology of carbapenemase‐producing Enterobacterales isolated from dog and cat faeces submitted to veterinary laboratories in the USA

“…Awareness is a key first step so veterinarians may implement strategies such as advanced infection prevention strategies and judicious use of antimicrobials to limit the spread of CPE. In addition, local and regional public health agencies need to consider approaches for tracking and responding to CPE cases in companion animals, including implementing or promoting reporting from veterinarians and developing surveillance programs (KuKanich et al., 2023). A collaborative, One Health approach will be required between animal and human health professionals to prevent morbidity and mortality caused by CPE in people and animals.…”

Pharmacokinetic and Pharmacodynamic Analysis of the Oxacephem Antibiotic Flomoxef against Extended-Spectrum β-Lactamase-Producing Enterobacterales from Dogs

“…Carbapenems are frequently used for the treatment of ESBL-E infections in human medicine, but there is a risk of developing carbapenemresistant Enterobacterales (CRE) [4,5]. Although the true prevalence of CRE in companion animals is unknown, there have been several reports on CRE isolation in dogs and cats worldwide [6,7]. Such prevalence of CRE in companion animals represents not only a serious concern in veterinary medicine but also a potential public health threat due to its transmission to surrounding people through close contact [8].…”