One hundred and five Kaposi sarcoma patients: a clinical study in Xinjiang, Northwest of China

Wu, Xiujuan; Pu, Xiongming; Kang, Xiaojian; Halifu, Yilinuer; An, Caixia; Zhang, D.-Z.; Yakeya, Buwajieer; Mijit, J.

doi:10.1111/jdv.12349

Cited by 34 publications

(52 citation statements)

References 53 publications

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“…According to official estimates, there are more than 10 000 HIV‐positive persons living in Xinjiang . Previous data have shown that KSHV infection is endemic in the area and there is a high incidence of KS, particularly among Uygur ethnicity . KS is one of the most frequently occurring malignant tumor in individuals infected with HIV‐1 in Western and African countries .…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus among HIV‐infected Uygurs in Xinjiang, China

Liu

Fang

Zhou

et al. 2017

Journal of Medical Virology

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Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), which primarily affects human immunodeficiency virus (HIV)-infected adults with advanced immunodeficiency. Xinjiang province in China is an endemic area for Kaposi's sarcoma (KS), however, currently, only limited data for KSHV infection among HIV-infected individuals living in this endemic area is available. A cross-sectional study of 86 HIV positive participants was conducted in Xinjiang, China from 2014 through 2015. Plasma samples were collected and screened for KSHV and HIV infection. HIV pol gene and KSHV ORF-K1 gene were amplified and sequenced, genotypes were determined by phylogenetic analysis. Over all, prevalence was 48.9% (42/86; 95%CI 38.4-59.3%) for KSHV. Only CRF07_BC subtype has been identified among all these HIV positive individuals, while the subtype A and C of KSHV were detected in the participants. Meanwhile, we found that those with high CD4 counts (>500) showed a lower anti-KSHV titer, compared with other groups. Our study indicated a high prevalence of KSHV among HIV positive individuals in Xinjiang, China. Thus, management of HIV/AIDS patients should include KSHV screen and should consider the risk of KSHV-associated malignancies.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus among HIV‐infected Uygurs in Xinjiang, China

Liu

Fang

Zhou

et al. 2017

Journal of Medical Virology

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“…It mostly affects elderly men of Italian, Jewish, or Mediterranean origin [3]. In China, more than 90 % of KS cases, including classic KS (CKS) and AIDS-associated KS (AIDS-KS), have occurred in Xinjiang, especially among Uyghur patients [4–6]. Many studies have demonstrated that human herpes virus 8 (HHV-8) is an important pathogen in KS, and more than 95% of patients with KS have been infected with HHV-8 [7].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-126-3p suppresses cell proliferation by targeting PIK3R2 in Kaposi's sarcoma cells

Zhao

Kang

et al. 2016

Oncotarget

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Kaposi's sarcoma is a highly vascular tumor of lymphatic endothelial origin. Many deregulated miRNAs, including miR-126-3p, have been identified in Kaposi's sarcoma tissues. miR-126-3p is the most highly endothelial-specific miRNA that regulates vascular integrity and angiogenesis. In this study, we aimed to determine the effect of miR-126-3p on Kaposi's sarcoma cells through transfection of a miRNA mimic and inhibitor. Moreover, we searched the target gene (PIK3R2) of miR-126-3p using bioinformatics software and further verified PIK3R2 using luciferase reporter assays, Real-time quantitative PCR (qRT-PCR) and western blot. The results demonstrated that miR-126-3p inhibited cell proliferation, arrested cell cycle progression, induced cell apoptosis, and inhibited cell invasion of SLK cells. The bioinformatics analysis and luciferase reporter assay revealed that PIK3R2 mRNA is a direct target of miR-126-3p. Moreover, the level of expression of the PIK3R2 gene was downregulated in SLK cells transfected with miR-126-3p siRNAs. Therefore, our data demonstrated that miR-126-3p is a tumor suppressor miRNA that acts by targeting PIK3R2 in Kaposi's sarcoma cells. These findings contribute to our understanding of the molecular mechanisms underlying Kaposi's sarcoma.

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“…2 In practice, KS generally presents as one or multiple, asymptomatic, red-purple or brown patches, plaques or nodular skin lesions in the lower extremities. 3 C-Kit is involved in cell signal transduction in many different cell types and it encodes tyrosine kinase receptor (CD117). Furthermore, c-Kit is a mutagenic effective proto-oncogene with a stem-cell factor (SCF) as a ligand, and it leads to tumor growth through impairment of cellular growth regulation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Şehitoğlu

Bedir

Cüre

et al. 2016

An. Bras. Dermatol.

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Backgroundc-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter.ObjectiveTo investigate c-Kit expression and intensity in patients with Kaposi's sarcoma (KS) and to investigate the relation between Ki-67 proliferation and MPV.MethodsA total of 32 patients, diagnosed with classic cutaneous KS, were included in this study. We reevaluated the histopathological reports with the preparations, confirmed the diagnosis and then determined the patients' histopathological stages. c-Kit expression and Ki-67 proliferation were investigated immunohistochemically in KS cases, while MPV in all cases was checked.ResultsAlthough c-Kit expression was detected in 22 cases (68.8%), it was not expressed in 10 cases (31.2%). We detected 8 cases with + (25%), 6 with ++ (18.8%) and 8 with +++ (25%). Ki-67 expression was 5.0% (min-max 1.0-20.0). Relapse was observed in 5 cases (15.6%) out of 32. There was positive correlation between c-Kit expression and MPV (rs=0.598, p<0.001), and between c-Kit intensity and MPV (rs=0.588, p<0.001).Conclusionc-Kit is highly positive in KS. c-Kit positivity indicates a high risk of tumor growth, invasion and relapse. Furthermore, c-Kit expression stimulates megakaryocytes to release young and large thrombocytes into the periphery. Thus, high MPV, c-Kit expression and immunostaining intensity indicate high invasion and relapse in KS subjects.

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One hundred and five Kaposi sarcoma patients: a clinical study in Xinjiang, Northwest of China

Cited by 34 publications

References 53 publications

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus among HIV‐infected Uygurs in Xinjiang, China

Seroprevalence of Kaposi's sarcoma‐associated herpesvirus among HIV‐infected Uygurs in Xinjiang, China

MicroRNA-126-3p suppresses cell proliferation by targeting PIK3R2 in Kaposi's sarcoma cells

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

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