One-hundred-and-six gamete intra-Fallopian transfer procedures with donor semen

Formigli, L.; Coglitore, M.T.; Roccio, C.; Belotti, G.; Stangalini, A; Formigli, G.

doi:10.1093/oxfordjournals.humrep.a137140

Cited by 6 publications

(1 citation statement)

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“…An ectopic rate of 4.0% of all pregnancies or 1.5% of transfers has been quoted by the Society for Assisted Reproductive Technology and the American Society for Reproductive Medicine in their analysis of 1472 clinical pregnancies subsequent to 4202 gamete intra-Fallopian transfer (GIFT) retrieval cycles initiated in the USA in 1993 (Society for Assisted Reproductive Technology/American Society for Reproductive Medicine, 1995). A similar rate of ectopic pregnancies following GIFT has been repeated in the subsequent report (Society for Assisted Reproductive Technology/ American Society for Reproductive Medicine, 1998) and this is comparable with that reported previously (Formigli et al, 1990).…”

Section: Risk Factorssupporting

confidence: 89%

Extra-uterine pregnancy following assisted conception treatment

Abusheikha

Salha²,

Brinsden³

2000

Human Reproduction Update

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Ectopic pregnancy may be the only life-threatening disease in which prevalence has increased as mortality has declined. The most prominent theory to explain this phenomenon involves increased sensitivity of serum beta-human chorionic gonadotrophin (HCG) immunoassay and improved quality of transvaginal ultrasound, combined with a heightened awareness and increased suspicion of the condition among clinicians which has allowed early detection of ectopic pregnancy. Laparotomy, once the standard treatment of ectopic pregnancy, has been replaced almost entirely by operative laparoscopy. This is associated with a shorter hospital stay, fewer post-operative analgesic requirements, reduced costs and lower risk of adhesion formation. Laparotomy, however, remains necessary in cases with haemodynamic instability and with exceptional locations, e.g. cervical, abdominal and interstitial implantation. In selected cases, non-surgical management has also obtained high success rates. Among medical therapies, the most common is systemic or local administration of methotrexate. The other option is expectant management involving follow-up using serial serum HCG measurements and ultrasound scans. Thus, life-threatening ectopic pregnancy is now evolving into a medical disease, with the possibility of lower-cost treatment, faster recovery and higher subsequent fertility. In this review we assess the risk of extra-uterine implantation after assisted conception treatment, the accuracy of various diagnostic tools and focus on the efficacy, safety and the fertility outcomes of surgical and nonsurgical management of ectopic pregnancy.

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Section: Risk Factorssupporting

confidence: 89%