One Hundred Cases of Nephrolithotomy Under Hypothermia

Wickham, J. E. A.; Coe, Nicholas P.W.; Ward, J.P.

doi:10.1016/s0022-5347(17)59832-8

Cited by 100 publications

(25 citation statements)

References 2 publications

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“…If, unexpectedly, renal circulation has to be inter rupted for more than 60 min, renal preservation is continued with regional hypothermia. Fernando et al (5)(6)(7) have shown that for an optimum protec tive effect, inosine must be administered directly into the renal artery and Wickham et al (25) have developed a technique of puncturing the clamped renal artery for the appropriate application in clinical use. A double-lumen bai loon-tipped cathe ter inserted percutaneously prior to the operation, renders this technically difficult and potentially dangerous maneuver unnecessary and permits the combination of inosine protection with balloon occlusion of the renal artery, and if necessary, with hypothermic perfusion, in a most simple manner.…”

Section: Discussionmentioning

confidence: 99%

“…Regional hypothermia either by surface cooling (2,25) or transarterial hypothermic perfusion (14) reliably prevents ischemic damage of the kidney when extensive in situ surgery requires lengthy interruption of renal circulation. In spite of tech nical refinements, however, all of these methods are tedious and time-consuming, and simpler pro cedures of equal effectiveness would be advantage ous.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Inosine: Alternative or Adjunct to Regional Hypothermia in the Prevention of Post-Ischemic Renal Failure?

Marberger¹,

Günther²,

Alken³

et al. 1980

Eur Urol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Inosine: Alternative or Adjunct to Regional Hypothermia in the Prevention of Post-Ischemic Renal Failure?

Marberger¹,

Günther²,

Alken³

et al. 1980

Eur Urol

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“…Regional hypothermia either by surface cooling [1,2] or transarterial hypothermic perfusion [3] prevents isch emic damage to the kidney when extensive in situ surgery requires lengthy clamping of the renal artery. However, in spite of technical improvements all these methods are tedious and time consuming and simpler techniques would be favourable.…”

Section: Introductionmentioning

confidence: 99%

Renal Blood Flow Alterations after Temporary Ischemia

Pflüger¹,

Maier²,

Wagner³

et al. 1983

Eur Urol

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“…In order to accomplish complete removal of infected, large renal calculi, various forms of advanced open sur gery have been used [14][15][16], but new technical achieve ments radically have altered the therapeutic approach. Despite the fact that the new modalities often result in higher percentage of retained stone fragments in the kid ney after treatment [17][18][19], these methods nevertheless are attractive because they are less invasive.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Acidification of Urine in Patients Treated for Infected Renal Stones

Wall

Tiselius²

1990

Urol Int

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The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2g of methenamine hippurate or 1.8 g of ascorbic acid. Long-term treatment with ammonium chloride in doses between 1.5 and 3 g was given to 11 patients in order to reduce the risk of new stone formation or growth of fragments remaining after disintegration of infected renal stones. Biochemical stone analyses showed struvite in 9 of the treated stones, and urine cultures verified the presence of urease-producing bacteria in 10 patients. Apart from ammonium chloride, the patients were treated with antibiotics, in 4 patients continuously and in the others during periods from 2 to 34 months. The patients were followed for an average period of 32 months. No adverse reactions were recorded with the dosage used. Initially, 6 patients were stone-free, whereas 5 had residual stone fragments with a largest diameter ranging from 4 to 20 mm. At follow-up, 2 patients were still stone-free, and of 5 patients with residual fragments 1 showed stable disease and 3 an improved stone situation. In 5 patients, 3 of whom had residual stone fragments, antibiotic treatment had been interrupted without infectious relapse. Our conclusion is that long-term urinary acidification is possible despite residual fragments and that it might be a beneficial therapeutic supplement to patients who have been treated for infected renal stones, particularly if disintegrated stone material resides in the kidney following extracorporeal or percutaneous lithotripsy procedures.

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One Hundred Cases of Nephrolithotomy Under Hypothermia

Cited by 100 publications

References 2 publications

Inosine: Alternative or Adjunct to Regional Hypothermia in the Prevention of Post-Ischemic Renal Failure?

Inosine: Alternative or Adjunct to Regional Hypothermia in the Prevention of Post-Ischemic Renal Failure?

Renal Blood Flow Alterations after Temporary Ischemia

Long-Term Acidification of Urine in Patients Treated for Infected Renal Stones

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