One Hundred Thirty-Two Consecutive Pediatric Liver Transplants Without Hospital Mortality

Bröering, Dieter C.; Kim, Jong-Sun; Mueller, Teresa; Fischer, Lutz; Ganschow, Rainer; Bicak, Turan; Müeller, Lars; Hillert, C.; Wilms, Christian; Hinrichs, Bernd; Helmke, K.; Pothmann, W.; Burdelski, M.; Rogiers, Xavier

doi:10.1097/01.sla.0000146148.01586.72

Cited by 93 publications

(95 citation statements)

References 33 publications

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“…Similar to that shown in Broering and associates, 3 we found that the most common cause of liver failure in children was biliary atresia and Wilson disease, suggesting the important role of early diagnosis to diminish the incidence of liver failure. Regarding cause of liver failure, we found no differences between children older or younger than 2 years.…”

Section: Farzad Vafaei Et Al/experimental and Clinical Transplantatiosupporting

confidence: 73%

“…These components of metabolic syndrome can increase the risk of cardiovascular disease. [1][2][3][4] As shown in a cross-sectional survey on adult liver transplant, 53% of patients had hypertension, 51% had hyperlipidemia, 37% had hyperglycemia, and 32% of patients had increased waist circumference at least 6 months after operation, with metabolic syndrome observed in 44.5%. 1 Some predisposing factors of metabolic syndrome after liver transplant are immunosuppressive drugs, higher age at time of operation, being male, higher body mass index (BMI) before transplant, pretransplant DM, underlying liver disease, and higher BMI in donors.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, posttransplant complications with vascular origin can cause transplant rejection or retransplant. 3 In long-term follow-up of pediatric liver transplant recipients, preoperation obesity has correlated with high mortality rate after transplant. 6 Fifteen to 21% of children are overweight or have severe obesity before transplant.…”

Section: Introductionmentioning

confidence: 99%

“…1 A return to ordinary lifestyle activities with normalized hypermetabolic state (versus that seen with liver insufficiency) and normal diet can cause progressive weight gain in these patients. [2][3][4] Determination of the predisposing factors contributing to mortality in patients with progressive liver insufficiency remains a challenging issue. In addition, determining the optimal time for transplant and the effective factors on short-term and long-term survival are debatable topics in this field.…”

Section: Introductionmentioning

confidence: 99%

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Vafaei

Dehghani²,

Malekhoseini³

et al. 2018

Exp Clin Transplant

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Objectives: Metabolic syndrome components, such as being overweight or having hypertension, hyperlipidemia, or diabetes mellitus, are common complications after liver transplant in pediatric patients with probable multifactorial causes and increase the risk of cardiovascular complications in adulthood. In this study, our aim was to evaluate the prevalence of these components both before and after transplant surgery. Materials and Methods: Our study included all children having liver transplant at our institution over a period of 20 years who were under 18 years old and had at least 6 months of posttransplant follow-up. Prevalence of metabolic syndrome components and pretransplant and posttransplant laboratory data of patients were evaluated. Results: Over the 20-year study period, 391 liver transplant patients were included in our study, in which 167 were girls (42.7%) and 224 were boys (57.3%). Patients showed a posttransplant hyperlipidemia rate of 7.5%, hyperglycemia rate of 22%, hypertension rate of 9.6%, and metabolic syndrome rate of 50.2%. Pretransplant, the rate of patients with metabolic syndrome was 10.5%. Conclusions: Our study confirmed that the prevalence of metabolic syndrome in patients after liver transplant increases dramatically and should be explored with further research.

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Section: Farzad Vafaei Et Al/experimental and Clinical Transplantatiosupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vafaei

Dehghani²,

Malekhoseini³

et al. 2018

Exp Clin Transplant

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“…Portal venous stenosis is relatively a rare vascular complication when compared with arterial and biliary complications after liver transplantation, affecting 2-14% of transplant recipients in children [3][4][5][6]. Since the first successful treatment using percutaneous balloon dilatation by Raby et al [7], several methods of portal venoplasty have been reported for the treatment of portal venous stenosis using percutaneous transhepatic [8], transjugular intrahepatic [9], or transileocolic venous [10] approaches.…”

Section: Introductionmentioning

confidence: 99%

Transileocolic venous balloon dilatation for the management of primary and recurrent portal venous stenosis after living donor liver transplantation in children

et al. 2007

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Portal venous stenosis is relatively a rare complication after liver transplantation in children and it sometimes leads to life threatening event due to gastrointestinal bleeding or graft failure. Recently, balloon dilatation has been widely accepted as a treatment of choice for the management of portal venous stenosis. The purpose of this study was to evaluate the feasibility of transileocolic venous balloon dilatation for the management of primary and recurrent portal venous stenosis after living donor liver transplantation (LDLT) in children. The records of 57 pediatric liver transplants were retrospectively reviewed. Nine patients (15.8%) with portal venous stenosis were identified. Seven symptomatic children with portal venous stenosis underwent balloon dilatation. Two approaches were employed for balloon dilatation; the transileocolic venous approach and the percutaneous transhepatic approach. In patients with recurrent stenosis, careful follow-up was carried out while they were asymptomatic. Twelve balloon dilatations were performed in seven children with primary or recurrent portal venous stenoses. The initial technical success rate was 91.7% (11/12), while 6 out of 12 (50.0%) procedures resulted in recurrent stenosis. Five out of six recurrent stenoses required repeated balloon dilatation. The clinical success rate of balloon dilatation in our study was 85.7% (6/7). Other than recurrent stenosis, two procedure-related complications occurred. In conclusion, transileocolic venous balloon dilatation was a safe and effective procedure for portal venous stenosis after LDLT in children.

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Special Considerations for Liver Transplantation in Children

Burdelski¹,

Rogiers²

2006

Medical Care of the Liver Transplant Patient

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Burdelski M. Liver transplantation in children. Acta PEdiatr 1994;(Suppl 395):27--30. Stockholm.Liver transplantation has become the curative surgical therapy of end-stage acute, chronic and metabolic liver disease. This has been made possible by improvements in surgical techniques, such as segmental liver transplantation and by improvements in liver preservation. In parallel, advances in immunosuppression and anti-infective therapy have been achieved. As a result of this progress there is an increasing demand for liver transplantation which raises questions for ethical and socioeconomic consideration. 0 Children, liver transplantation

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One Hundred Thirty-Two Consecutive Pediatric Liver Transplants Without Hospital Mortality

Cited by 93 publications

References 33 publications

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Transileocolic venous balloon dilatation for the management of primary and recurrent portal venous stenosis after living donor liver transplantation in children

Special Considerations for Liver Transplantation in Children

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