One in Four Dies of Cancer. Questions About the Epidemiology of Malignant Tumours

Weiß, Christel

doi:10.1007/978-3-030-63749-1_2

Cited by 16 publications

(6 citation statements)

References 14 publications

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“…The anti-cancer effect of resveratrol (20-100 µg/mL for 24 h) and the function of sodium/lithium/calcium exchanger in relation to calcium ions were investigated in HeLa cells [145]. This therapeutic approach, employing siNCLX-mediated gene silencing and drug therapy with resveratrol, demonstrated a disruption of calcium homeostasis, an increase in caspase (3,8,9) mRNA expressions, and DNA damage, all of which resulted in apoptotic cell death [145]. Ca 2+ overload killed HeLa cells in response to the inhibition of mitochondrial Ca 2+ extrusion together with resveratrol therapy [145].…”

Section: Effects Of Resveratrol On Calcium Homeostasismentioning

confidence: 99%

“…Affecting people of all ages and backgrounds, it has a profound impact on society [2]. According to the World Health Organization, one in six deaths is caused by cancer, making it the second leading cause of death around the world [3]. Recent advancements in biomedical research have highlighted the role of phytochemicals as potential therapeutic anti-cancer agents [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Kursvietiene,

Kopustinskiene,

Staneviciene

et al. 2023

Antioxidants

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Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in the oncological applications of phytochemicals, particularly polyphenols, resveratrol—a naturally occurring polyphenolic stilbene derivative—has emerged as a candidate of interest. This review analyzes the pleiotropic anti-cancer effects of resveratrol, including its modulation of apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, and metastasis, its interaction with cancer stem cells and the tumor microenvironment. The effects of resveratrol on mitochondrial functions, which are crucial to cancer development, are also discussed. Future research directions are identified, including the elucidation of specific molecular targets, to facilitate the clinical translation of resveratrol in cancer prevention and therapy.

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Section: Effects Of Resveratrol On Calcium Homeostasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Kursvietiene,

Kopustinskiene,

Staneviciene

et al. 2023

Antioxidants

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show abstract

“…Globally, cancer is the second leading cause of death, accounting for one in six deaths. In 2018, approximately 9.6 million people died of cancer worldwide, and an increasing trend in the incidence is currently observed [1]. Based on this information, increasing attention is being paid to developing methods to prevent cancer through chemoprevention.…”

Section: Introductionmentioning

confidence: 99%

Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

Cecerska-Heryć,

Wiśniewska,

Serwin

et al. 2024

IJMS

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Malignant tumors are the second most common cause of death worldwide. More attention is being paid to the link between the body’s impaired oxidoreductive balance and cancer incidence. Much attention is being paid to polyphenols derived from plants, as one of their properties is an antioxidant character: the ability to eliminate reactive oxygen and nitrogen species, chelate specific metal ions, modulate signaling pathways affecting inflammation, and raise the level and activity of antioxidant enzymes while lowering those with oxidative effects. The following three compounds, resveratrol, quercetin, and curcumin, are polyphenols modulating multiple molecular targets, or increasing pro-apoptotic protein expression levels and decreasing anti-apoptotic protein expression levels. Experiments conducted in vitro and in vivo on animals and humans suggest using them as chemopreventive agents based on antioxidant properties. The advantage of these natural polyphenols is low toxicity and weak adverse effects at higher doses. However, the compounds discussed are characterized by low bioavailability and solubility, which may make achieving the blood concentrations needed for the desired effect challenging. The solution may lie in derivatives of naturally occurring polyphenols subjected to structural modifications that enhance their beneficial effects or work on implementing new ways of delivering antioxidants that improve their solubility and bioavailability.

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“…One in four people die of cancer, making it the second leading cause of death globally. 8 Apart from the high proliferation rate, one way in which cancer cells become dominant is by inducing the growth of capillaries from pre-existing blood vessels towards their site—an event called angiogenesis. 9 This neovasculature system provides tumors with nutrients and oxygen just like normal cells and is important for their growth and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Reinstating apoptosis using putative Bcl-xL natural product inhibitors: Molecular docking and ADMETox profiling investigations

Boyenle

Ogunlana

Oyedele

et al. 2023

Journal of Taibah University Medical Sciences

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One in Four Dies of Cancer. Questions About the Epidemiology of Malignant Tumours

Cited by 16 publications

References 14 publications

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Can Compounds of Natural Origin Be Important in Chemoprevention? Anticancer Properties of Quercetin, Resveratrol, and Curcumin—A Comprehensive Review

Reinstating apoptosis using putative Bcl-xL natural product inhibitors: Molecular docking and ADMETox profiling investigations

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