One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above

Klipstein, Sigal; Regan, Meredith M.; Ryley, David A.; Goldman, Marlene B.; Alper, Michael M.; Reindollar, Richard H.

doi:10.1016/j.fertnstert.2005.02.020

Cited by 115 publications

(111 citation statements)

References 20 publications

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“…Several of these found that the woman's age decisively affected the rates when autologous oocytes are used. Other studies not included in this Table confirm this (16,17).…”

Section: Cumulative Pregnancy and Live Birth Ratessupporting

confidence: 76%

Analysis of the truth in advertising on the efficacy provided by assisted reproduction clinics

2017

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This paper analyses the efficacy data from assisted reproduction clinics, obtained from both scientific society reports and from studies published in specialised journals, in order to compare them with information published by Spanish assisted reproduction clinics on their websites. It aims to verify whether this information matches the reality of the findings in the media analysed or, in contrast, differs from the aforementioned scientific evidence. Our study shows marked discrepancies between the evidence of existing statistical data, and figures published by most of the clinics on their websites, which could constitute false advertising.Key words: assisted reproduction clinics, live birth rate, pregnancy rate, in-vitro fertilisation, intracytoplasmic sperm injection, false advertising Análisis sobre la autenticidad de la publicidad sobre la eficacia de clínicas de reproducción asistida Resumen: Este estudio analiza los datos de eficacia de clínicas de reproducción asistida, obtenidos tanto de informes de sociedades científicas como de estudios publicados en revistas especializadas, para compararlos con la información publicada por las clínicas de reproducción asistida de España en sus sitios web. El objetivo es verificar si esta información es conforme a los hallados en informes y revistas o, por el contrario, difiere de la evidencia científica mencionada. Nuestro estudio demuestra marcadas discrepancias entre la evidencia de datos estadísticos existentes y las cifras publicadas por la mayoría de los sitios web de las clínicas, lo cual constituye falsa publicidad.Palabras clave: clínicas de reproducción asistida, frecuencia de nacimientos vivos, frecuencia de embarazos, fecundación in vitro, inyección intracitoplásmica de espermatozoides, publicidad falsa Análise da verdade na publicidade sobre a eficácia fornecida pelas clínicas de reprodução assistida Resumo: Este artigo analisa os dados de eficácia de clínicas de reprodução assistida, obtidas de relatórios da sociedade científica e de estudos publicados em revistas especializadas, a fim de compará-los com informações publicadas por clínicas de reprodução assistida espanholas em seus websites. O artigo visa verificar se esta informação coincide com a realidade dos resultados encontrados nos meios de comunicação analisados ou, por outro lado, difere da evidência científica acima mencionada. Nosso estudo mostra discrepâncias entre a evidência dos dados estatísticos existentes e indicadores publicados pela maioria das clínicas em seus sites, que podem constituir falsa publicidade.Palavras-chave: clínicas de reprodução assistida, taxa de natalidade, taxa de fecundidade, fertilização in vitro, injeção intracitoplasmática de espermatozoide, false publicidade

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“…Several of these found that the woman's age decisively affected the rates when autologous oocytes are used. Other studies not included in this Table confirm this (16,17).…”

Section: Cumulative Pregnancy and Live Birth Ratessupporting

confidence: 76%

Analysis of the truth in advertising on the efficacy provided by assisted reproduction clinics

2017

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Section: Introductionmentioning

confidence: 99%

“…In particular the number of women 43 years and older seeking IVF treatment is also on the rise, but there is little data available regarding treatment outcomes [6,11,12,19,24]. For many years, the upper limits for allowing IVF attempts were arbitrarily chosen (usually age 41 or 42 years) and strictly enforced by some centers [11]. Recent studies have reported a reasonable success rate up to 44 years of age [11,24] and it is only recently that the Society for Assisted Reproductive Technology (SART) has begun to provide data on cycle characteristics and pregnancy outcomes for patients aged 43-44 utilizing their own oocytes.…”

Section: Introductionmentioning

confidence: 99%

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

Çetinkaya

Siano

Benadiva

et al. 2013

J Assist Reprod Genet

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Purpose The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond. Methods Retrospective analysis of clinical pregnancy and live birth rates in168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs. Results In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3 % and 5.3 % per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p>0.05). Conclusions Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.

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“…Klipstein et al [4] reported that CD3 FSH values correlate with pregnancy, live birth, and pregnancy loss rates. Additionally, in their review of 2,705 cycles, they reported that the highest CD3 FSH level in a woman achieving a pregnancy was 18.0 mIU/mL, and that the highest CD3 FSH in a woman delivering a live child was 15.4 mIU/mL.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to factors influencing the outcome of IVF-ET, Tsafrir et al [1] noted in their retrospective analysis of 1,217 IVF cycles in women aged C 40 years that none of 10 patients treated after 45 years of age delivered successfully. Klimpstein et al [4] reported that the highest cycle day 3 follicle stimulating hormone (CD3 FSH) level in a 43-year-old woman achieving pregnancy was 18.0 mIU/mL and the highest CD3 FSH in a 40-year-old woman delivering a live child was 15.4 mIU/mL in their review of 2,705 cycles. Age and CD3 FSH level may thus provide useful indicators for treatment cut-off; however, an indicator for treatment cut-off based on the clinical course would be a more useful and more readily identified parameter for Japanese female infertility patients aged C 40 years.…”

Section: Introductionmentioning

confidence: 99%

Cancellation of in vitro fertilization treatment cycles predicts treatment outcome in female infertility patients aged 40 years or older

Sugimoto

Hashimoto

Takahashi

et al. 2011

Reprod Medicine & Biology

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Purpose To investigate potential indicators of in vitro fertilization (IVF) treatment outcome for female infertility patients aged C 40 years based on the clinical course. Methods We retrospectively examined results of 111 female infertility patients aged C 40 years undergoing IVF treatment. We investigated the relationship between treatment cycle cancellation and the final outcome of IVF treatment in female infertility patients aged C 40 years.

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One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above

Cited by 115 publications

References 20 publications

Analysis of the truth in advertising on the efficacy provided by assisted reproduction clinics

Analysis of the truth in advertising on the efficacy provided by assisted reproduction clinics

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

Cancellation of in vitro fertilization treatment cycles predicts treatment outcome in female infertility patients aged 40 years or older

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